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Usage

Uses

Used in Research and Development:
2-T-Butylthiophene is used as a chemical intermediate for the synthesis of more complex compounds, particularly in the field of organic chemistry. Its aromatic structure makes it a valuable component in the creation of various chemical products.
Used in Chemical Synthesis:
In the chemical industry, 2-T-Butylthiophene is employed as a building block for the production of other organic compounds. Its reactivity and structural properties contribute to the development of new materials and substances with potential applications in various sectors.
Used in Pharmaceutical Research:
2-T-Butylthiophene is utilized as a starting material in the synthesis of pharmaceutical compounds. Its unique chemical structure allows for the exploration of new drug candidates with potential therapeutic applications.
Used in Material Science:
In the field of material science, 2-T-Butylthiophene is used as a component in the development of new materials with specific properties, such as conductivity, stability, or reactivity. Its incorporation into these materials can lead to advancements in areas like electronics, energy storage, and sensors.

InChI:InChI=1/C8H12S/c1-8(2,3)7-5-4-6-9-7/h4-6H,1-3H3

Upstream product

• 188290-36-0 thiophene 
• 507-20-0 tertiary butyl chloride 
• 115-11-7 isobutene 
• 463-82-1 2,2-dimethylpropane 
• 75-65-0 tert-butyl alcohol 
• 1003-09-4 2-bromothiophene 
• 93425-02-6 2-bromo-5-(tert-butyl)thiophene 
• 507-19-7 t-butyl bromide 
• 5857-39-6 2-thienylmercury chloride 
• 53119-59-8 2,5-dibromo-3-t-butylthiophene 
• 86119-84-8 phosphoric acid 
• 75-15-0 carbon disulfide 
• 7646-78-8 tin(IV) chloride 

Downstream Products

• 29880-63-5 1-[5-(1,1-Dimethylethyl)-2-thienyl]ethanone 
• 29212-25-7 5-(tert-butyl)thiophene-2-carboxylic acid 
• 71972-86-6 C₂₃H₂₇NO₂S₂ 
• 150499-77-7 2-(5-tert-butyl-2-thienyl)ethyl tosylate 
• 117013-13-5 bis(5-t-butyl-2-thienyl)diphenyltin(IV) 
• 150483-85-5 5-tert-butylthiophene-2-carbaldehyde phenylhydrazone 
• 149228-14-8 5,5'-di-tert-butyl-2,2'-bithiophene 
• 15898-92-7 6,6-Dimethyloenanthsaeure 
• 685120-65-4 5-tert-butyl-thiophene-2-carboxylic acid amide 
• 832113-93-6 5-tert-butyl-2-thiophenecarboxylic acid chloride 
• 142396-76-7 3,3-dibenzyl-5-tert-butyl-2(3H)-thiophenone 
• 142396-90-5 2,2-dibenzyl-4-tert-butyl-2H-thiete 
• 142396-81-4 3-benzyl-5-tert-butyl-3-methyl-2(3H)-thiophenone 
• 142396-91-6 2-benzyl-4-tert-butyl-2-methyl-2H-thiete 

Relevant academic research and scientific papers

A Bithiophene-Promoted ppm Levels of Palladium-Catalyzed Regioselective Hydrosilylation of Terminal Allenes

A bithiophene?alkyne-based compound was synthesized and first utilized as a ligand for the selective hydrosilylation of allenes with primary and secondary phenylsilanes. It shows high selectivity towards the production of branched allylsilanes with a wide range of allenes. It is worth mentioning that the catalytic loading of the palladium can be reduced to 500 ppm. This work opens a new front of using bidentate thiophene ligand as a reaction promoter in transition-metal-catalyzed organic reaction. (Figure presented.).

E-H (E = R3Si or H) bond activation by B(C6F 5)3 and heteroarenes; Competitive dehydrosilylation, hydrosilylation and hydrogenation

In the presence of B(C6F5)3 five-membered heteroarenes undergo dehydrosilylation and hydrosilylation with silanes. The former, favoured on addition of a weak base, produces H2 as a by-product making the process catalytic in B(C6F5) 3 but also enabling competitive heteroarene hydrogenation. the Partner Organisations 2014.

Catalytic transformations of alkylthiophenes

The transformations of alkylthiophenes in the presence of amorphous aluminosilicate and decationated zeolite HNaY were studied. Substituted thiophenes with R = 2- and 3-Me, 2-Et, and 2-iso-Pr undergo dealkylation to thiophene with close rates, migration of the alkyl group from the 9α- to the β-position of the thiophene ring (or in the opposite direction with an elevated rate), and decomposition with H2S elimination. The dealkylation rate of 2-substituted thiophenes with a branched-chain radical (R = iso-Pr, terf-Bu) is much higher and the elimination rate with this radical is lower than those for normal-chain radicals; the isomerization step is virtually absent. Di-, tri-, and tetrasubstituted thiophenes with R = Et and iso-Pr undergo stepwise dealkylation, which is facilitated by an increase in the degree of substitution on the thiophene ring. Thiophene and its lower homologues can be obtained by the transformation of a mixture of high-molecular thiophenes. Copyright

CANNABINOID RECEPTOR LIGANDS

There are disclosed compounds of the formula I: or a pharmaceutically acceptable salt of the compound, which exhibit anti-inflammatory and immunomodulatory activity. Also disclosed are pharmaceutical compositions containing said compounds.

Synthesis of some Thiophenium Bis(t-butoxycarbonyl)methylides

Thiophene derivatives react with di-t-butyl diazomalonate in the presence of rhodium(II) carboxylates to yield thiophenium bis(t-butoxycarbonyl)methylides.Rhodium(II) hexanoate is a more efficient catalyst than rhodium(II) acetate, shortening reaction times and increasing yields of the ylides.Series of 2-halogeno-, 2-alkyl-, 2-benzyl-5-halogeno-, and 2-benzyl-5-alkyl-thiophenium ylides are described.Whilst 2-methyl-, 2-ethyl-, and 2-isopropyl-thiophenes readily form the ylides in good yield, 2-t-butylthiophene appears to undergo further reaction to yield 1,3-bis-t-butoxycarbonyl-2-(3-t-butyl-6,6-bis-t-butoxycarbonyl-2-thioniabicyclohex-3-en-2-yl)methanide (2) whose structure has been confirmed by X-ray crystallography.

SYNTHESIS AND CHARACTERIZATION OF ALKYL-, HALO- AND HETEROSUBSTITUTED DERIVATIVES OF THE POTENT PHOTOTOXIN &α-TERTHIENYL

A number of derivatives of α-terthienyl were prepared including a series of naturally occurring compounds.A description of the syntheses of some new compounds, including 5-iodo, 5,5''-diiodo, 5,5''-diformyl, 5,5''-di-tert butyl, 5-tert-butyl, 5-tert-butoxy, 5-trimethylsilyl, 5-thiomethyl, 5,5''-dithiomethyl and 5-carboxyl-5''-(trimethylsilyl)-2,2':5',2''-terthienyl is also given.An analysis of the 1H NMR data of the derivatives is presented.

TERTIARY BUTYLATION OF FIVE MEMBERED HETEROCYCLES. A UPS STUDY

The reaction of 2-chloromercuryfuran and t-butylbromide was studied by UV photoelectron spectroscopy.During the reaction the formation of t-butylfuran, 2,5-di-t-butylfuran, t-butylchloride, isobutylene and furan were found.In accordance with the experimental observations a novel reaction mechanism has been proposed.The first fast and the second slow step of the reaction has been interpreted.The corresponding thiophene derivative gave similar results.

STABLE HETEROARENIUM IONS - VIII SOME TRANSFORMATIONS OF ALKYLTHIOPHENIUM IONS AND NEW SYNTHESIS OF 2-t-BUTYLTHIOPHENE

The ratio of isomeric ?-complexes formed from thiophene, t-butyl chloride and AlCl3 was found to be changed while keeping at room temperature whitin 1-2 days.This allows to obtain after deprotonation 2-t-butylthiophene containing only 3percent of 3-isomer.Transformations of ?-complexes formed by protonation of individual 2- and 3-t-butylthiophenes in the presence of AlCl3 have been studied and there was found that isomerization and deprotonation took place during their storage resulting in mixtures of 2- and 3-t-butylthiophenes (the ratio 97:3) which contained considerable quantities of 2,4-di-t-butylthiophene.Deprotonation of t-butylthiophenium ions in the presence of acetone leads to the formation of respective t-butylsubstituted dimethyldithienylmethanes.