29886-67-7

Usage

Uses

Used in Pharmaceutical Industry:
4-(Thiophen-3-yl)phenol 97 is used as a building block for the synthesis of pharmaceutical compounds due to its potential antioxidant and anti-inflammatory properties, which make it a candidate for drug development.
Used in Agrochemical Industry:
In the agrochemical industry, 4-(Thiophen-3-yl)phenol 97 is utilized as a starting material for the creation of various agrochemicals, contributing to its role in the development of products for agricultural applications.
Used in Organic Synthesis:
4-(Thiophen-3-yl)phenol 97 is used as a reagent in organic synthesis, facilitating the production of a range of organic compounds for different applications across various industries.
Used in Specialty Chemicals Production:
As a starting material, 4-(Thiophen-3-yl)phenol 97 is essential in the production of specialty chemicals, indicating its broad utility in chemical manufacturing and innovation.

InChI:InChI=1/C10H8OS/c11-10-3-1-8(2-4-10)9-5-6-12-7-9/h1-7,11H

Upstream product

• 82437-75-0 3-(4-methoxy-phenyl)-thiophene 
• 6165-69-1 Thien-3-ylboronic acid 
• 106-41-2 4-bromo-phenol 
• 30068-21-4 2-(4-methoxyphenyl)-1-methyl-2-propanol 
• 51431-73-3 1-(but-2-en-2-yl)-4-methoxybenzene 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 540-38-5 p-Iodophenol 

Downstream Products

• 164399-48-8 2,3-epoxy-4-(3-thienyl)-phenoxypropane 
• 929917-85-1 (S)-2-[4-(4-thiophen-3-yl-phenoxy)-phenoxymethyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 929918-40-1 (R)-2-[4-(4-Thiophen-3-yl-phenoxy)-phenoxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 929918-41-2 (R)-2-[4-(4-thiophen-2-yl-phenoxy)-phenoxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1339035-57-2 4-(3-thienyl)phenyl 3-[1-(6-chloropyridazin-3-yl)-5-(4-fluorophenyl)-1H-pyrazol-3-yl]propanoate 
• 119492-73-8 3-(4-fluorophenyl)thiophene 
• 1330616-54-0 C₃₂H₃₈O₂S₃ 
• 1330616-52-8 C₃₂H₃₈O₂S₂ 
• 1330616-47-1 3-(4-hexyloxyphenyl)-3'-(4-(ω-bromo)hexyloxyphenyl)-2,2'-bithiophene 
• 1330616-42-6 2-bromo-3-(4-(ω-bromo)hexyloxyphenyl)thiophene 
• 1330616-37-9 C₁₆H₁₉BrOS 
• 1262545-31-2 4,5-[4-(thiophen-3-yl)-phenoxy]-phthalonitrile 
• 1196485-58-1 4-[4-(4-thiophen-3-yl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

A mild and practical method for deprotection of aryl methyl/benzyl/allyl ethers with HPPh2andtBuOK

A general method for the demethylation, debenzylation, and deallylation of aryl ethers using HPPh2andtBuOK is reported. The reaction features mild and metal-free reaction conditions, broad substrate scope, good functional group compatibility, and high chemical selectivity towards aryl ethers over aliphatic structures. Notably, this approach is competent to selectively deprotect the allyl or benzyl group, making it a general and practical method in organic synthesis.

Photo-Fries reaction in acetoxyphenyl thiophenes

Two new acetoxyphenyl thiophenes with different conjugation length and undergoing the photo-Fries reaction upon exposure to UV light are presented. These molecules have been characterized in solution by means of different spectroscopic techniques in order to study the evolution and selectivity of the photo-induced reaction. During such a reaction, isosbestic points appear in the UV–vis spectra, indicating a good selectivity of the reaction for both the derivatives. By means of IR measurements, we follow the reaction and determine the kinetics and the quantum yield. The photoproducts are isolated by HPLC and characterized by 1H-NMR whose results confirm the formation of the ortho derivative as the most probable one and we estimate the degree of conversion of the reaction. High-level quantum mechanical calculations both in gas and solvated phase are employed to strongly support the interpretation of the experimental results, and assess the reaction product.

Preparing method of aromatic nitrile or alkenyl nitrile compound

The invention discloses a preparing method of an aromatic nitrile or alkenyl nitrile compound. The preparing method comprises the following step that under protection of inert gas, an aryl or heteroaryl sulphonate compound shown in a formula II or an alkenyl sulphonate compound shown in a formula IV and a cyanation reagent are subjected to a cross-coupling reaction as is shown below in a solvent under the condition of the presence of a nickel complex, metal zinc and an additive to obtain the aromatic nitrile or alkenyl nitrile compound, wherein 4-dimethylamiopryidine (DMAP) is adopted as the additive, and zinc cyanide is adopted as the cyanation reagent. By means of the preparing method, cyanation of aryl sulphonate, heteroaryl sulphonate or alkenyl sulphonate can be simply and efficientlyachieved with a cheap catalysis system; moreover, the functional group compatibility and substrate universality are good, and a better application prospect and higher using value are provided for achieving industrial synthesis of the aromatic nitrile or alkenyl nitrile compound.

Nickel-Catalyzed Cyanation of Phenol Derivatives with Zn(CN)2 Involving C-O Bond Cleavage

An efficient nickel-catalyzed cyanation of aryl sulfonates, fluorosulfonates, and sulfamates with Zn(CN)2 was developed, which provides a facile access to the nitrile products in generally good to excellent yields. The reaction is accomplished by using NiII complex as the precatalyst and DMAP as the additive. The method also displays wide functional group compatibility; for example, keto, methoxy, N,N-dimethylamino, cyano, ester, and pyridyl groups are well-tolerated during the reaction process.

AMINATION AND HYDROXYLATION OF ARYLMETAL COMPOUNDS

In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the aromatic compound may be unsubstituted, substituted, or contain one or more heteroatoms within the rings of the aromatic compound. The methods described herein may be carried out without the need for transition metal catalysts or harsh reaction conditions.

Palladium salt and functional reduced graphene oxide complex: in situ preparation of a generally applicable catalyst for C-C coupling reactions

A novel Pd catalyst was designed by affording Pd2+ salt on the surface of functional reduced graphene oxide (FRGO), providing a new cheap and stable in situ prepared palladium catalyst for C-C coupling reactions, including the Heck reaction, Suzuki reaction, C-H bond functionalization reactions of thiophenes, and terminal alkyne C-H activation and homocoupling.

Thiol functionalized diphenyl bithiophene for monomolecular bistable layers

Diphenyl bithiophene derivatives (DPBTs), known for their electrical bistable behavior, have been used in bulk resistive memory cells. In this article, we present the design and synthesis of a ω-alkyl thiol functionalized 3,3′-diphenyl 2,2′-bithiophene; s

BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION

The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders. The compounds have general formula Ψ: An example is

Electrochemical and photophysical properties of a novel polythiophene with pendant fulleropyrrolidine moieties: Toward "double cable" polymers for optoelectronic devices

We have prepared a novel bithiophene carrying a fulleropyrrolidine substituent. Its electrochemical polymerization affords an electron donor-acceptor material that has been studied by means of electrochemical and spectroscopic techniques. The results from

A novel polythiophene with pendant fullerenes: Toward donor/acceptor double-cable polymers

The synthesis of a novel bithiophene with a pendant fullerene substituent and its electrochemical polymerisation are reported; light induced ESR measurements on the electrodeposited films reveal a photoinduced electron transfer from the donor cable (polyt