29917-04-2

Upstream product

• 6325-93-5 p-nitrobenzenesulfonamide 

Downstream Products

• 141693-72-3 N-<2,3-Bis(methylthio)cyclopropenylidene>-p-nitrobenzenesulfonamide 
• 141693-75-6 N-<2,3-Bis(dimethylamino)cyclopropenylidene>-p-nitrobenzenesulfonamide 
• 141693-69-8 N-<2,3-Diphenylcyclopropenylidene>-p-nitrobenzenesulfonamide 
• 52918-25-9 N-p-Nitrobenzolsulfonyl-Se,Se-diphenylselenilimin 
• 180625-76-7 N-(p-nitrophenylsulfonyl)-S-(1-methyl-1,3-dihydro-2,1-benzisothiazol-3-yliden)sulfimid 
• 180625-92-7 N,N'-bis-(p-nitrophenylsulfonyl)-1-methyl-2,1-benzisothiazolium-3-sulfinamidinat 
• 180625-82-5 N-(p-nitrophenylsulfonyl)-S-(2-benzyl-2,3-dihydro-1,2-benzisothiazol-3-yliden)sulfimid 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 1254470-64-8 N-[2-(phenyl)prop-2-en-1-yl]-N-(4-nitrobenzenesulfonyl)amide 
• 95194-84-6 N-(4-nitrobenzenesulfonyl) phenyl sulfonimidoyl chloride 

Relevant academic research and scientific papers

Application of N-halogeno-N-sodiobenzenesulfonamide reagents to the selective detection of 5-methylcytosine in DNA sequences

To surmount the challenges of the locus determination and accurate quantification of 5-methyl-2′-deoxycytidine (5MedC) in DNA fragments that contain multiple 5MedC residues, we designed and synthesized two N-halogeno-N-sodiobenzenesu

Synthesis of Pyrroles via Consecutive 6π-Electrocyclization/Ring-Contraction of Sulfilimines

We present a modular, synthetic entry to polysubstituted pyrroles employing readily available 2,5-dihydrothiophenes. Ring-opening of the heterocycle provides access to a panel of 1,3-dienes which undergo pyrrole formation in the presence of inexpensive chloramine-T trihydrate. The transformation is conducted in an open flask and proceeds at ambient temperatures (23 °C) in nondry solvents. A careful adjustment of the electronics and sterics of the 1,3-diene precursor allows for the isolation of key intermediates. DFT studies identified a reaction mechanism that features a 6π-electrocyclization of a sulfilimine intermediate followed by spontaneous ring-contraction to reveal the pyrrole skeleton.

SULFONAMIDE ANALOGUES OF GALIELLALACTONE

Disclosed are sulfonamide analogues of galiellactone of formula (I) as STAT3-inhibitors for use in the treatment of a STAT3 signaling related disorder, e.g. solid cancers, hematological cancers, benign tumors, hyperproliferative diseases, inflammations, autoimmune diseases, graft or transplant rejections, delayed physiological function of grafts or transplants, neurodegenerative diseases and viral infections. The sulfonamide comprises a cyclic substituent.

Structure-activity considerations in kinetics and mechanism of chlorine exchange between chloramine-T and secondary amines

To study the mechanism of N-chlorination of secondary amines by chloramine-T, the kinetics of the reactions of some aromatic-substituted analogues of N-chlorobenzenesulfonamide with various secondary amines were determined. The importance of amine basicity and reactivity of the N-Cl bond of the N-chlorobenzenesulfonamide was also assessed. The results indicate that a mechanism involving the un-ionized species of both reactants (i.e., a molecular mechanism), rather than an ionic mechanism, is operating and that the reaction most likely proceeds via a six-membered-ring transition state that incorporates a water molecule.