299189-19-8Relevant academic research and scientific papers
Lipoic acid derivatives, their preparation, and pharmaceutical compositions containing them
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, (2008/06/13)
The invention concerns novel lipoic acid derivatives, which have an inhibiting action with respect to NO-synthase enzymes producing nitrogen monoxide NO and/or are agents enabling the regeneration of antioxidants or entities trapping reactive oxygen speci
Novel lipoic acid analogues that inhibit nitric oxide synthase.
Harnett, Jeremiah J,Auguet, Michel,Viossat, Isabelle,Dolo, Christine,Bigg, Dennis,Chabrier, Pierre-E
, p. 1439 - 1442 (2007/10/03)
The synthesis and biological activity of novel lipoic acid analogues are reported. Lipoic acid and structural homologues coupled to arylthiophene amidine via carboxamide linkers are metabolic antioxidants capable of protecting neuronal cells against glutamate cytotoxicity, preventing loss of intracellular glutathione, and inhibit nitric oxide synthase.
