94838-58-1

Basic information

• Product Name: TERT-BUTYL (4-NITROBENZYL)CARBAMATE
• Synonyms: TERT-BUTYL (4-NITROBENZYL)CARBAMATE;tert-butyl N-[(4-nitrophenyl)methyl]carbamate
• CAS NO: 94838-58-1
• Molecular Formula: C₁₂H₁₆N₂O₄
• Molecular Weight: 252.26644
• Mol File: 94838-58-1.mol
• Article Data: 30

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: TERT-BUTYL (4-NITROBENZYL)CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL (4-NITROBENZYL)CARBAMATE(94838-58-1)
• EPA Substance Registry System: TERT-BUTYL (4-NITROBENZYL)CARBAMATE(94838-58-1)

Safety Data

• Hazardous Substances Data: 94838-58-1(Hazardous Substances Data)

Usage

General Description

Tert-butyl (4-nitrobenzyl)carbamate, also known as Boc-4-nitrobenzylamine, is a chemical compound commonly used in the process of organic synthesis. It is a derivative of tert-butyl carbamate, which is often employed as a protecting group in peptide synthesis. Boc-4-nitrobenzylamine is a yellow solid that is soluble in organic solvents and can be easily dissolved in various reaction mixtures. Its main applications include the protection of amines during chemical reactions and the synthesis of pharmaceutical compounds and other organic molecules. TERT-BUTYL (4-NITROBENZYL)CARBAMATE is considered to be stable and safe for handling, but should be used with caution in laboratory settings.

Upstream product

• 7409-30-5 p-nitrobenzylamine 
• 41840-28-2 S-tert-butoxycarbonyl-4,6-dimethyl-2-mercaptopyrimidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 18600-42-5 4-nitrobenzylamine hydrochloride 
• 17271-88-4 p-nitrobenzyl azide 
• 619-73-8 4-nitrobenzyl chloride 
• 1142-27-4 p-nitrophenyl N,N-dimethylsulphamate 
• 1314538-55-0 potassium tert-butyl N-[(trifluorolambda-4-boranyl)methyl]carbamate 
• 100-02-7 4-nitro-phenol 
• 100-00-5 4-chlorobenzonitrile 
• 619-72-7 4-nitrobenzonitrile 
• 62133-07-7 2-(4-nitrobenzyl)-1H-isoindole-1,3(2H)-dione 
• 39628-94-9 4-nitrobenzyl methanesulfonate 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Downstream Products

• 1612898-23-3 (4-dimethylaminophenyl)methanamine trifluoroacetate 

Relevant articles and documents

Identification of First-in-Class Inhibitors of Kallikrein-Related Peptidase 6 That Promote Oligodendrocyte Differentiation

Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) that causes severe motor, sensory, and cognitive impairments. Kallikrein-related peptidase (KLK)6 is the most abundant serine protease secreted in the CNS, mainly by oligodendrocytes, the myelin-producing cells of the CNS, and KLK6 is assumed to be a robust biomarker of MS, since it is highly increased in the cerebrospinal fluid (CSF) of MS patients. Here, we report the design and biological evaluation of KLK6's low-molecular-weight inhibitors, para-aminobenzyl derivatives. Interestingly, selected hit compounds were selective of the KLK6 proteolytic network encompassing KLK1 and plasmin that also participate in the development of MS physiopathology. Moreover, hits were found noncytotoxic on primary cultures of murine neurons and oligodendrocyte precursor cells (OPCs). Among them, two compounds (32 and 42) were shown to promote the differentiation of OPCs into mature oligodendrocytes in vitro constituting thus emerging leads for the development of regenerative therapies.

3. 4 - diphenyl - 4H - 1, 2, 4 - triazole derivative and its preparation method and application (by machine translation)

The invention discloses 3, 4 - diphenyl - 4H - 1, 2, 4 - triazole derivative and its preparation method and application. In particular, the invention relates to the formula (I) structure of 3, 4 - diphenyl - 4H - 1, 2, 4 - triazole derivatives, its stereoisomers or its pharmaceutically acceptable salt, formula (I) in the definition of each substituent is as defined in the specification. These structure of novel compound with heat shock protein HSP90 inhibitory activity, can be used for treating cancer, neurodegenerative diseases, inflammatory diseases, autoimmune diseases, ischemic brain injury and the like, it has broad application prospects. (by machine translation)

NOVEL DIAMINE, POLYAMIC ACID, AND POLYIMIDE

To provide a novel diamine, and a polyimide precursor and a polyimide using it. A diamine represented by the formula (1): wherein each of X1 and X5 which are independent of each other, is a single bond or the like; each of X2 /