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299207-90-2

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  • Methyl 4-(4-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylate

    Cas No: 299207-90-2

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299207-90-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 299207-90-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,9,2,0 and 7 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 299207-90:
(8*2)+(7*9)+(6*9)+(5*2)+(4*0)+(3*7)+(2*9)+(1*0)=182
182 % 10 = 2
So 299207-90-2 is a valid CAS Registry Number.

299207-90-2Relevant articles and documents

Development of dihydropyridone indazole amides as selective rho-kinase inhibitors

Goodman, Krista B.,Cui, Haifeng,Dowdell, Sarah E.,Gaitanopoulos, Dimitri E.,Ivy, Robert L.,Sehon, Clark A.,Stavenger, Robert A.,Wang, Gren Z.,Viet, Andrew Q.,Xu, Weiwei,Ye, Guosen,Semus, Simon F.,Evans, Christopher,Fries, Harvey E.,Jolivette, Larry J.,Kirkpatrick, Robert B.,Dul, Edward,Khandekar, Sanjay S.,Yi, Tracey,Jung, David K.,Wright, Lois L.,Smith, Gary K.,Behm, David J.,Bentley, Ross,Doe, Christopher P.,Hu, Erding,Lee, Dennis

, p. 6 - 9 (2007)

Rho kinase (ROCK1) mediates vascular smooth muscle contraction and is a potential target for the treatment of hypertension and related disorders. Indazole amide 3 was identified as a potent and selective ROCK1 inhibitor but possessed poor oral bioavailabi

NOVEL COMPOUNDS

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Page/Page column 25-26, (2008/06/13)

Novel inhibitors of Rho-kinases are disclosed.

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