299207-90-2Relevant academic research and scientific papers
Development of dihydropyridone indazole amides as selective rho-kinase inhibitors
Goodman, Krista B.,Cui, Haifeng,Dowdell, Sarah E.,Gaitanopoulos, Dimitri E.,Ivy, Robert L.,Sehon, Clark A.,Stavenger, Robert A.,Wang, Gren Z.,Viet, Andrew Q.,Xu, Weiwei,Ye, Guosen,Semus, Simon F.,Evans, Christopher,Fries, Harvey E.,Jolivette, Larry J.,Kirkpatrick, Robert B.,Dul, Edward,Khandekar, Sanjay S.,Yi, Tracey,Jung, David K.,Wright, Lois L.,Smith, Gary K.,Behm, David J.,Bentley, Ross,Doe, Christopher P.,Hu, Erding,Lee, Dennis
, p. 6 - 9 (2007)
Rho kinase (ROCK1) mediates vascular smooth muscle contraction and is a potential target for the treatment of hypertension and related disorders. Indazole amide 3 was identified as a potent and selective ROCK1 inhibitor but possessed poor oral bioavailabi
Enantioselective synthesis of dihydropyridinones via NHC-Catalyzed Aza-Claisen reaction
Wanner, Benedikt,Mahatthananchai, Jessada,Bode, Jeffrey W.
supporting information; experimental part, p. 5378 - 5381 (2011/12/02)
N-Heterocyclic carbene catalyzed aza-Claisen annulations of enals or their α-hydroxyenone surrogates with vinylogous amides afford dihydropyridinones. The reaction proceeds with a broad range of substrates, and no nitrogen protecting group is required.
NOVEL COMPOUNDS
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Page/Page column 25-26, (2008/06/13)
Novel inhibitors of Rho-kinases are disclosed.
