methyl 4-(4-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylate

Base Information

• Chemical Name: methyl 4-(4-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylate
• CAS No.: 299207-90-2
• Molecular Formula: C14H14FNO3
• Molecular Weight: 263.268
• Hs Code.: 2933399990
• Mol file: 299207-90-2.mol

Synonyms:methyl 4-(4-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate;

Chemical Property of methyl 4-(4-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylate

Chemical Property:

• PSA: 55.40000
• LogP: 2.20500

Purity/Quality:

95%-98% ^*data from raw suppliers

Methyl 4-(4-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylate ^*data from reagent suppliers

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Technology Process of methyl 4-(4-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylate

There total 2 articles about methyl 4-(4-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(E)-1-(4-fluorophenyl)-4-hydroxy-4-methylpent-1-en-3-one (1156005-78-5) + methyl 3-aminocrotonate (21731-17-9) → methyl 4-(4-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylate (299207-90-2)

Guidance literature:

With 2-(2,4,6-trimethyl-phenyl)-2,5,6,7-tetrahydro-pyrrolo[2,1-c] [1,2,4]triazol-4-ylium perchlorate; 3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone; potassium carbonate; In toluene; at 40 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ol202272t

Reference yield: 20.0%

cycl-isopropylidene malonate (2033-24-1) + 4-fluorobenzaldehyde (459-57-4) + acetoacetic acid methyl ester (105-45-3) → methyl 4-(4-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylate (299207-90-2)

Guidance literature:

With ammonium acetate; acetic acid; for 3.5h; Heating;

DOI:10.1021/jm0609014

Reference yield: 100.0%

methyl 4-(4-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylate (299207-90-2) + methyl iodide (74-88-4) → methyl 4-(4-fluorophenyl)-1,2-dimethyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylate (864082-39-3)

Guidance literature:

With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 1h;

upstream raw materials:

cycl-isopropylidene malonate

4-fluorobenzaldehyde

acetoacetic acid methyl ester

(E)-1-(4-fluorophenyl)-4-hydroxy-4-methylpent-1-en-3-one

Downstream raw materials:

4-(4-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylic acid

methyl 4-(4-fluorophenyl)-1,2-dimethyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylate

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