29922-97-2Relevant academic research and scientific papers
Enzyme-artificial enzyme interactions as a means for discriminating among structurally similar isozymes
Selvakumar, Karuthapandi,Motiei, Leila,Margulies, David
supporting information, p. 4892 - 4895 (2015/05/05)
We describe the design and function of an artificial enzyme-linked receptor (ELR) that can bind different members of the glutathione-S-transferase (GST) enzyme family. The artificial enzyme-enzyme interactions distinctly affect the catalytic activity of the natural enzymes, the biomimetic, or both, enabling the system to discriminate among structurally similar GST isozymes.
Amide derivatives of ethacrynic acid: Synthesis and evaluation as antagonists of Wnt/β-catenin signaling and CLL cell survival
Jin, Guangyi,Lu, Desheng,Yao, Shiyin,Wu, Christina C.N.,Liu, Jerry X.,Carson, Dennis A.,Cottam, Howard B.
experimental part, p. 606 - 609 (2009/09/06)
A series of amides of ethacrynic acid was prepared and evaluated for their ability to inhibit Wnt signaling and decrease the survival of CLL cells. Several of the most potent derivatives were active in the low micromolar range. Reduction of the α,β-unsatu
Design, Synthesis, and Testing of Potential Antisickling Agents. 7. Ethacrynic Acid Analogues
Abraham, D. J.,Mehanna, A. S.,Williams, F. S.,Cragoe, E. J.,Woltersdorf, O. W.
, p. 2460 - 2467 (2007/10/02)
In search of a drug to treat sickle cell anemia, several analogues of the diuretic ethacrynic acid (ECA) have been synthesized and found equivalent in antigelling potency to ECA, but they have moderate or little diuretic activity.Structure-activity studie
Compounds useful in treating sickle cell anemia
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, (2008/06/13)
The present invention is directed to compounds of the general formula I and pharmaceutically acceptable salts thereof: STR1 wherein R=H or lower alkyl; R'=H, lower alkyl, benzyl, CH2 OH; A=(CH2)1 to 5, >C(CH3)s
