29922-97-2Relevant articles and documents
Enzyme-artificial enzyme interactions as a means for discriminating among structurally similar isozymes
Selvakumar, Karuthapandi,Motiei, Leila,Margulies, David
supporting information, p. 4892 - 4895 (2015/05/05)
We describe the design and function of an artificial enzyme-linked receptor (ELR) that can bind different members of the glutathione-S-transferase (GST) enzyme family. The artificial enzyme-enzyme interactions distinctly affect the catalytic activity of the natural enzymes, the biomimetic, or both, enabling the system to discriminate among structurally similar GST isozymes.
Design, Synthesis, and Testing of Potential Antisickling Agents. 7. Ethacrynic Acid Analogues
Abraham, D. J.,Mehanna, A. S.,Williams, F. S.,Cragoe, E. J.,Woltersdorf, O. W.
, p. 2460 - 2467 (2007/10/02)
In search of a drug to treat sickle cell anemia, several analogues of the diuretic ethacrynic acid (ECA) have been synthesized and found equivalent in antigelling potency to ECA, but they have moderate or little diuretic activity.Structure-activity studie