29925-17-5 Usage
Uses
Used in Pharmaceutical Research:
RO 20-1724 is used as a research tool for studying cAMP-related functions in vascular cells, as it inhibits the release of cytokines and other inflammatory signals, as well as prevents the development of reactive oxygen species.
Used in Anti-inflammatory Applications:
RO 20-1724 is used as an anti-inflammatory agent due to its ability to inhibit the release of cytokines and other inflammatory signals, making it a potential candidate for treating inflammatory conditions.
Used in Psoriasis Treatment:
RO 20-1724 is used as a selective PDE4 inhibitor for patients with plaque psoriasis, providing relief from the symptoms and improving the condition of the skin.
Used in Drug Development:
RO 20-1724 is used as a lead compound in the development of new drugs targeting PDE4, which may have potential applications in various diseases and conditions related to inflammation and cAMP signaling pathways.
Biological Activity
Widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC 50 = 2.0 μ M). Also available as part of the Phosphodiesterase Inhibitor Tocriset? .
Biochem/physiol Actions
Inhibitor of cAMP phosphodiesterase. IC50 33 μM in vascular smooth muscle of the aorta.
References
1) Soderling et al. (1998), Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase; Proc. Natl. Acad. Sci. USA, 95 8991
2) Nicholson et al. (1991), Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes; Trends Pharmacol. Sci., 12 19
Check Digit Verification of cas no
The CAS Registry Mumber 29925-17-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,9,2 and 5 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 29925-17:
(7*2)+(6*9)+(5*9)+(4*2)+(3*5)+(2*1)+(1*7)=145
145 % 10 = 5
So 29925-17-5 is a valid CAS Registry Number.
InChI:InChI=1/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)/t12-/m0/s1
29925-17-5Relevant academic research and scientific papers
Direct Synthesis of Unprotected 2-Azidoamines from Alkenes via an Iron-Catalyzed Difunctionalization Reaction
Makai, Szabolcs,Falk, Eric,Morandi, Bill
, p. 21548 - 21555 (2021/01/11)
Unprotected, primary 2-azidoamines are versatile precursors to vicinal diamines, which are among the most common motifs in biologically active compounds. Herein, we report their operationally simple synthesis through an iron-catalyzed difunctionalization of alkenes. A wide array of alkene substrates are tolerated, including complex drug-like molecules and a tripeptide. Facile derivatizations of the azidoamine group demonstrate the versatility of this masked diamine motif in chemoselective, orthogonal transformations. Applications of the methodology in the concise synthesis of RO 20-1724 as well as in the formal total syntheses of both (±)-hamacanthin B and (±)-quinagolide further demonstrate the broad synthetic potential of this highly functional-group-tolerant reaction.
