29926-01-0Relevant academic research and scientific papers
Formation and Disproportionation of Xanthenols to Xanthenes and Xanthones and Their Use in Synthesis
Shi, Zeyu,Chen, Si,Xiao, Qiong,Yin, Dali
, p. 3334 - 3343 (2021/02/05)
A facile and versatile strategy employing TiCl4-mediated cyclization followed by a Cannizzaro reaction has been developed for the synthesis of various xanthene derivatives. The reaction proceeded smoothly to afford both xanthenes/xanthones or their sulfur derivatives and tolerated a wide range of electronically diverse substrates. Using this methodology, pranoprofen was synthesized in three steps in 59% overall yield from commercially available starting materials.
Reaction of benzyne with salicylaldehydes: General synthesis of xanthenes, xanthones, and xanthols
Okuma, Kentaro,Nojima, Akiko,Matsunaga, Nahoko,Shioji, Kosei
supporting information; experimental part, p. 169 - 171 (2009/06/20)
The reaction of salicylaldehydes with benzyne prepared from o-trimethylsilyphenyl triflate and CsF gave xanthenes and xanthones. When the reaction was carried out under basic conditions, 9-hydroxyxanthenes (xanthols) were obtained in good yields.
