29940-82-7Relevant academic research and scientific papers
Chiral Br?nsted Acid Catalyzed Dynamic Kinetic Asymmetric Hydroamination of Racemic Allenes and Asymmetric Hydroamination of Dienes
Lin, Jin-Shun,Li, Tao-Tao,Jiao, Guan-Yuan,Gu, Qiang-Shuai,Cheng, Jiang-Tao,Lv, Ling,Liu, Xin-Yuan
supporting information, p. 7092 - 7096 (2019/04/26)
The first highly efficient and practical chiral Br?nsted acid catalyzed dynamic kinetic asymmetric hydroamination (DyKAH) of racemic allenes and asymmetric hydroamination of unactivated dienes with both high E/Z selectivity and enantioselectivity are described herein. The transformation proceeds through a new catalytic asymmetric model involving a highly reactive π-allylic carbocationic intermediate, generated from racemic allenes or dienes through a proton transfer mediated by an activating/directing thiourea group. This method affords expedient access to structurally diverse enantioenriched, potentially bioactive alkenyl-containing aza-heterocycles and bicyclic aza-heterocycles.
Stereoselective synthesis of a MCHr1 antagonist
Andersen, Denise,Storz, Thomas,Liu, Pingli,Wang, Xin,Li, Leping,Fan, Pingchen,Chen, Xiaoqi,Allgeier, Alan,Burgos, Alain,Tedrow, Jason,Baum, Jean,Chen, Ying,Crockett, Rich,Huang, Liang,Syed, Rashid,Larsen, Robert D.,Martinelli, Mike
, p. 9648 - 9655 (2008/03/17)
(Chemical Equation Presented) Melanin-concentrating hormone (MCH) is implicated in the feeding behavior in mammals affording a potential target to control overeating in people. Compound 1 (AMG 076) has been identified as a potent MCHr1 antagonist for the
