88578-93-2Relevant academic research and scientific papers
Chiral Br?nsted Acid Catalyzed Dynamic Kinetic Asymmetric Hydroamination of Racemic Allenes and Asymmetric Hydroamination of Dienes
Lin, Jin-Shun,Li, Tao-Tao,Jiao, Guan-Yuan,Gu, Qiang-Shuai,Cheng, Jiang-Tao,Lv, Ling,Liu, Xin-Yuan
supporting information, p. 7092 - 7096 (2019/04/26)
The first highly efficient and practical chiral Br?nsted acid catalyzed dynamic kinetic asymmetric hydroamination (DyKAH) of racemic allenes and asymmetric hydroamination of unactivated dienes with both high E/Z selectivity and enantioselectivity are described herein. The transformation proceeds through a new catalytic asymmetric model involving a highly reactive π-allylic carbocationic intermediate, generated from racemic allenes or dienes through a proton transfer mediated by an activating/directing thiourea group. This method affords expedient access to structurally diverse enantioenriched, potentially bioactive alkenyl-containing aza-heterocycles and bicyclic aza-heterocycles.
PROCESS FOR PREPARING GABAPENTIN
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Page/Page column 15, (2008/06/13)
A process for preparing gabapentin of formula 1, which comprises Formula (I) converting 1-allyl-cyclohexanecarboxaldehyde into 1-allyl-cyclohexanecarbonitrile; ozonizing 1-allyl-cyclohexanecarbonitrile to obtain 1-cyano-cyclohexaneacetaldehyde; acetalizing 1-cyano-cyclohexaneacetaldehyde with a suitable acetalizing agent to give the corresponding acetal and converting the latter into gabapentin.
SYNTHESYS OF UNNATURAL AMINO ACIDS: SPIRO-2-AZA-DECAN-CARBOXYLIC ACID
Teetz, V.,Gaul, H.
, p. 4483 - 4486 (2007/10/02)
Spiro-2-aza-alkan-carboxylic acids represent bulky proline analogues with increased lipophilicity.They are readily available from cyclic nitriles via alkylation with bromoacetaldehyde acetals, reduction to the corresponding amine, cyclisation to the
