299461-38-4Relevant academic research and scientific papers
Synthesis, characterisation, electronic spectra and electrochemical investigation of ferrocenyl-terminated dendrimers
Villalonga-Barber, Carolina,Vallianatou, Kalliopi,Georgakopoulos, Spyros,Steele, Barry R.,Micha-Screttas, Maria,Levin, Efrat,Gabriel Lemcoff
, p. 3885 - 3895 (2013/07/05)
Two new dodecaferrocenyl dendrimers have been prepared using a sixfold Sonogashira coupling reaction and sixfold Huisgen cycloaddition, respectively. In addition, a dendron containing four ferrocenyl groups has been synthesised by conventional synthetic methods. Electrochemical studies have shown that all the ferrocene units are electrochemically equivalent. Moreover, when treated with acid these compounds form multicharged methylium near-infrared-absorbing dendritic dyes with a high extinction coefficient.
Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties
Salerno, Loredana,Pittalà, Valeria,Romeo, Giuseppe,Modica, Maria N.,Siracusa, Maria A.,Di Giacomo, Claudia,Acquaviva, Rosaria,Barbagallo, Ignazio,Tibullo, Daniele,Sorrenti, Valeria
, p. 5145 - 5153 (2013/09/02)
A novel series of aryloxyalkyl derivatives of imidazole and 1,2,4-triazole, 17-31, was designed and synthesized as inhibitors of heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2). Some of these compounds were found to be good inhibitors of HO-1, in particular those carrying an imidazole moiety as azolyl group and a 3-bromo or 4-iodophenyl as aryl moiety. The most potent compounds 6 and 30 were selected and studied for their antitumor properties in a model of LAMA-84 R cell line overexpressing HO-1 and resistant to imatinib mesylate (IM), a tyrosine-kinase inhibitor used in the treatment of multiple types of cancer, most notably Philadelphia Chromosome positive (Ph+) Chronic Myelogenous Leukemia (CML). Results show that both 6 and 30 sensitized LAMA-84 R cell line to antitumor properties of IM.
5-Lipoxygenase inhibition by N-hydroxycarbamates in dual-function compounds
Lewis, Timothy A.,Bayless, Lynn,DiPesa, Alan J.,Eckman, Joseph B.,Gillard, Michel,Libertine, Lyn,Scannell, Ralph T.,Wypij, Donna M.,Young, Michelle A.
, p. 1083 - 1085 (2007/10/03)
A series of N-hydroxycarbamates containing a histaminergic H1 receptor antagonist pharmacophore was synthesized. In vitro assays determined the compounds had both histaminergic binding and 5-lipoxygenase inhibiting activities comparable to the
Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity
Lewis, Timothy A.,Young, Michelle A.,Arrington, Mark P.,Bayless, Lynn,Cai, Xiong,Collart, Philippe,Eckman, Joseph B.,Ellis, James L.,Ene, Doina G.,Libertine, Lyn,Nicolas, Jean-Marie,Scannell, Ralph T.,Wels, Bruce F.,Wenberg, Karen,Wypij, Donna M.
, p. 5591 - 5594 (2007/10/03)
Three different histaminergic H1 scaffolds were attached by various linkers to a single 5-LO scaffold. Both activities were observed in vitro. Pharmacokinetic properties of the compounds were evaluated and both a cetirizine-based compound and a
Compounds and methods for treatment of asthma, allergy and inflammatory disorders
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, (2008/06/13)
The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl peperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well
