299461-40-8Relevant academic research and scientific papers
5-Lipoxygenase inhibition by N-hydroxycarbamates in dual-function compounds
Lewis, Timothy A.,Bayless, Lynn,DiPesa, Alan J.,Eckman, Joseph B.,Gillard, Michel,Libertine, Lyn,Scannell, Ralph T.,Wypij, Donna M.,Young, Michelle A.
, p. 1083 - 1085 (2007/10/03)
A series of N-hydroxycarbamates containing a histaminergic H1 receptor antagonist pharmacophore was synthesized. In vitro assays determined the compounds had both histaminergic binding and 5-lipoxygenase inhibiting activities comparable to the
Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity
Lewis, Timothy A.,Young, Michelle A.,Arrington, Mark P.,Bayless, Lynn,Cai, Xiong,Collart, Philippe,Eckman, Joseph B.,Ellis, James L.,Ene, Doina G.,Libertine, Lyn,Nicolas, Jean-Marie,Scannell, Ralph T.,Wels, Bruce F.,Wenberg, Karen,Wypij, Donna M.
, p. 5591 - 5594 (2007/10/03)
Three different histaminergic H1 scaffolds were attached by various linkers to a single 5-LO scaffold. Both activities were observed in vitro. Pharmacokinetic properties of the compounds were evaluated and both a cetirizine-based compound and a
