6523-63-3

Basic information

• Product Name: 4-CYANO-4,4-DIPHENYLBUTANOIC ACID
• Synonyms: 4-CYANO-4,4-DIPHENYLBUTANOIC ACID
• CAS NO: 6523-63-3
• Molecular Formula: C₁₇H₁₅NO₂
• Molecular Weight: 265.31
• Mol File: 6523-63-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-CYANO-4,4-DIPHENYLBUTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYANO-4,4-DIPHENYLBUTANOIC ACID(6523-63-3)
• EPA Substance Registry System: 4-CYANO-4,4-DIPHENYLBUTANOIC ACID(6523-63-3)

Safety Data

• Hazardous Substances Data: 6523-63-3(Hazardous Substances Data)

Upstream product

• 2997-23-1 4-cyano-4,4-diphenyl-butyric acid ethyl ester 
• 931409-69-7 tert-butyl 4-cyano-4,4-diphenylbutanoate 
• 86-29-3 Diphenylacetonitrile 
• 53847-23-7 diphenylcyanomethylsodium 
• 292638-85-8 acrylic acid methyl ester 
• 6414-69-3 ethyl 3-iodopropanoate 

Downstream Products

• 2997-28-6 4-oxo-1-phenyl-1,2,3,4-tetrahydro-1-naphthalenecarboxamide 
• 16549-02-3 1-Cyan-1-phenyl-4-tetralon 
• 931410-13-8 5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-oxo-2,2-diphenylpentanenitrile 
• 1352814-80-2 5-[(3S)-3-phenoxypyrrolidin-1-yl]-2,2-diphenylpentanenitrile 
• 1337555-06-2 5-[(3S)-3-phenoxypyrrolidin-1-yl]-2,2-diphenylpentanamide 
• 93315-29-8 5-oxo-2,2-diphenylpentanenitrile 
• 1705-68-6 5-hydroxy-2,2-diphenylpentanenitrile 
• 1355533-23-1 5-(3-hydroxy-azetidin-1-yl)-5-oxo-2,2-diphenylpentanenitrile 
• 931409-66-4 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile 
• 1079781-31-9 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2 diphenyl hexanamide hydrochloride 
• 931409-24-4 PF-3635659 
• 132594-18-4 2,2-diphenyl-5-oxo-hexanenitrile 
• 1079781-24-0 5-[3-(3-methoxyphenoxy)azetidin-1-yl]-5-oxo-2,2-diphenylpentanenitrile 

Relevant articles and documents

Development of a scaleable synthesis of a geminal dimethyl tertiary amine as an inhaled muscarinic antagonist for the treatment of COPD

An efficient and scalable process for the synthesis of muscarinic antagonist, PF-3635659 1, is described, illustrating redesign of an analogue-targeted synthesis which contained a scale-limiting rhodium-activated C-H amination step. The final route includes a reproducible modified Bouveault reaction which has not previously been reported on a substrate of this complexity, or on such a scale with over 5 kg of the requisite gem-dimethylamine prepared via this methodology.

CARBOXAMIDE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS

The invention relates to compounds of Formula (I) processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.