6523-63-3

Upstream product

• 6414-69-3 ethyl 3-iodopropanoate 
• 86-29-3 Diphenylacetonitrile 
• 292638-85-8 acrylic acid methyl ester 
• 931409-69-7 tert-butyl 4-cyano-4,4-diphenylbutanoate 
• 2997-23-1 4-cyano-4,4-diphenyl-butyric acid ethyl ester 
• 53847-23-7 diphenylcyanomethylsodium 

Downstream Products

• 2997-22-0 2,2-diphenylpentanedioic acid 
• 931410-11-6 4-cyano-4,4-diphenylbutanoyl chloride 
• 2997-26-4 3,3-diphenyl-piperidine-2,6-dione 
• 2997-28-6 4-oxo-1-phenyl-1,2,3,4-tetrahydro-1-naphthalenecarboxamide 
• 16549-02-3 1-Cyan-1-phenyl-4-tetralon 
• 2997-27-5 4,4-diphenyl-glutaramic acid 
• 24052-89-9 3,3-diphenyl-2-pyrrolidinimine 
• 6309-36-0 3,3-diphenyl-2-pyrrolidone 
• 56562-04-0 1-(2-dimethylamino-ethyl)-3,3-diphenyl-pyrrolidin-2-one 
• 56561-97-8 1-(2-diethylamino-ethyl)-3,3-diphenyl-pyrrolidin-2-one 
• 54743-19-0 1-(2-dimethylamino-ethyl)-3,3-diphenyl-piperidine-2,6-dione 
• 101444-18-2 4-isocyanato-2,2-diphenyl-butyronitrile 
• 14702-25-1 2,2-diphenyl-pentanedioic acid anhydride 
• 27249-41-8 1-Carbamoyl-1-phenyl-4-tetralol 

Relevant academic research and scientific papers

Development of a scaleable synthesis of a geminal dimethyl tertiary amine as an inhaled muscarinic antagonist for the treatment of COPD

An efficient and scalable process for the synthesis of muscarinic antagonist, PF-3635659 1, is described, illustrating redesign of an analogue-targeted synthesis which contained a scale-limiting rhodium-activated C-H amination step. The final route includes a reproducible modified Bouveault reaction which has not previously been reported on a substrate of this complexity, or on such a scale with over 5 kg of the requisite gem-dimethylamine prepared via this methodology.

Inhalation by design: Novel tertiary amine muscarinic M3 receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease

A novel tertiary amine series of potent muscarinic M3 receptor antagonists are described that exhibit potential as inhaled long-acting bronchodilators for the treatment of chronic obstructive pulmonary disease. Geminal dimethyl functionality pr

CARBOXAMIDE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS

The invention relates to compounds of Formula (I) processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.