299897-90-8

Basic information

• Product Name: 2-NITRO-5-(1-PYRROLIDINYL)BENZENECARBOXAMIDE
• Synonyms: 2-NITRO-5-(1-PYRROLIDINYL)BENZENECARBOXAMIDE
• CAS NO: 299897-90-8
• Molecular Formula: C₁₁H₁₃N₃O₃
• Molecular Weight: 235.24
• Mol File: 299897-90-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 246-248°C
• Appearance: /
• CAS DataBase Reference: 2-NITRO-5-(1-PYRROLIDINYL)BENZENECARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NITRO-5-(1-PYRROLIDINYL)BENZENECARBOXAMIDE(299897-90-8)
• EPA Substance Registry System: 2-NITRO-5-(1-PYRROLIDINYL)BENZENECARBOXAMIDE(299897-90-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 299897-90-8(Hazardous Substances Data)

Upstream product

• 41994-44-9 5-chloro-2-nitrobenzoyl chloride 
• 123-75-1 pyrrolidine 
• 40763-96-0 2-nitro-5-chlorobenzamide 

Downstream Products

• 314768-96-2 2-amino-5-(pyrrolidin-1-yl)benzamide 

Relevant articles and documents

Synthesis and cytotoxicity of 6-pyrrolidinyl-2-(2-substituted phenyl)-4-quinazolinones

In our continuing search for potential anticancer candidates, 2-(3-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone (JJC-1) was selected as the lead compound. Starting 5-pyrrolidinyl-2-aminobenzamide was prepared using standard methodology from 5-chloro-2-ni

2-Aryl-4-Quinazolinones And Their Pharmaceutical Compositions

Provided is a compound of the formula I or a pharmaceutically acceptable salt, solvate or stereoisomer thereof: wherein Ar represents R5, R6, R7, R8, R1′, R2′, R3′, R4

6-alkylamino- and 2,3-dihydro-3′-methoxy-2-phenyl-4-quinazolinones and related compounds: Their synthesis, cytotoxicity, and inhibition of tubulin polymerization

As part of our continuing search for potential anticancer candidates among 2-phenyl-4-quinolones and 2-phenyl-4-quinazolinones, two series of 6,7,2′,3′,4′,5′-substituted 2-phenyl-4-quinazolinones and 6,2′,3′,4′,5′-substituted 2,3-dihydro-2-phenyl-4-quinazolinones were synthesized and evaluated for cytotoxicity and as inhibitors of tubulin polymerization. In general, a good correlation was found between the two activities. Five of the 6-substituted heterocyclic 2-phenyl-4-quinozolinones (37-51) showed significant cytotoxicity against a panel of human tumor cell lines with EC50 values in the low micromolar to nanomolar concentration ranges. Compound 38 was the most potent of these compounds, as well as the most potent inhibitor of tubulin polymerization in this series. The activity of 38 was in the same range as those of the antimitotic natural products, colchicine, podophyllotoxin, and combretastatin A-4. Substituted 2-phenyl-4-quinazolinones and 2,3-dihydro-2-phenyl-4-quinazolinones also displayed highly selective cytotoxicity against the ovarian cancer 1A9 and P-gp resistant KB-VIN cell lines.