299969-20-3Relevant articles and documents
Preparation of 1-D nanoparticle superstructures with tailorable thicknesses using gold-binding peptide conjugates
Hwang, Leekyoung,Chen, Chun-Long,Rosi, Nathaniel L.
, p. 185 - 187 (2011)
We describe the preparation of new 1-D gold nanoparticle superstructures with tailorable thicknesses formed using a self-assembled gold-binding peptide conjugate template and examine how the synthesis and assembly mechanism impacts the organization of the
Peptide-directed synthesis and assembly of hollow spherical CoPt nanoparticle superstructures
Song, Chengyi,Wang, Yang,Rosi, Nathaniel L.
, p. 3993 - 3995 (2013)
From "nano" to "super": Peptide conjugates that consist of cobalt-binding peptides terminated with tails of biphenyl units were used to direct the synthesis and assembly of hollow spherical superstructures of CoPt nanoparticles (see picture). These magnet
General method for the preparation of active esters by palladium-catalyzed alkoxycarbonylation of aryl bromides
De Almeida, Angelina M.,Andersen, Thomas L.,Lindhardt, Anders T.,De Almeida, Mauro V.,Skrydstrup, Troels
supporting information, p. 1920 - 1928 (2015/02/19)
A useful method was developed for the synthesis of active esters by palladium-catalyzed alkoxycarbonylation of (hetero)aromatic bromides. The protocol was general for a range of oxygen nucleophiles including N-hydroxysuccinimide (NHS), pentafluorophenol (PFP), hexafluoroisopropyl alcohol (HFP), 4-nitrophenol, and N-hydroxyphthalimide. A high functional group tolerance was displayed, and several active esters were prepared with good to excellent isolated yields. The protocol was extended to access an important synthetic precursor to the HIV-protease inhibitor, saquinavir, by formation of an NHS ester followed by acyl substitution.
Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants
Majumdar, Susruta,Subrath, Joan,Le Rouzic, Valerie,Polikar, Lisa,Burgman, Maxim,Nagakura, Kuni,Ocampo, Julie,Haselton, Nathan,Pasternak, Anna R.,Grinnell, Steven,Pan, Ying-Xian,Pasternak, Gavril W.
experimental part, p. 6352 - 6362 (2012/09/22)
3-Iodobenzoylnaltrexamide 1 (IBNtxA) is a potent analgesic acting through a novel receptor target that lack many side-effects of traditional opiates composed, in part, of exon 11-associated truncated six transmembrane domain MOR-1 (6TM/E11) splice variant
In silico-aided design of a glycan ligand of sialoadhesin for in vivo targeting of macrophages
Nycholat, Corwin M.,Rademacher, Christoph,Kawasaki, Norihito,Paulson, James C.
supporting information, p. 15696 - 15699,4 (2020/08/24)
Cell-specific delivery of therapeutic agents using ligand targeting is gaining interest because of its potential for increased efficacy and reduced side effects. The challenge is to develop a suitable ligand for a cell-surface receptor that is selectively
Structure-functional analysis of interactions of terminal deoxynucleotidyl transferase with new non-nucleoside substrates
Matyugina,Alexandrova,Jasco,Ivanov,Vasiliev,Lapteva,Khandazhinskaya,Kukhanova
experimental part, p. 342 - 348 (2010/06/16)
New non-nucleoside esters of phosphoric acid containing various hydrophobic groups, namely (1) N-(2-tripticencarbonyl)-4-aminobutyl; (2) 5-phenylsubstituted N-(2,4-dinitrophenyl)-4-aminobutyl; (3) N-(4-phenylbenzoyl)- and N-(4-(N-benzylamino)benzoyl)-2-aminoethyl groups, as well as (4) diphenylmethyl and fluorenyl groups were synthesized and studied as substrates of terminal deoxynucleotidyl transferase. With the exception of the two latter derivatives, all the analogues displayed substrate properties and could incorporate into the deoxyoligonucleotide 3′-end. As it was shown in biochemical experiments and by computer modeling, a linker joining the triphosphate and hydrophobic fragments of the molecule was necessary for these compounds to display substrate properties.
Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2
Greenfield, Alexander,Grosanu, Cristina,Dunlop, John,McIlvain, Beal,Carrick, Tikva,Jow, Brian,Lu, Qiang,Kowal, Dianne,Williams, John,Butera, John
, p. 4985 - 4988 (2007/10/03)
Excitatory amino acid transporters (EAATs) play a pivotal role in maintaining glutamate homeostasis in the mammalian central nervous system, with the EAAT-2 subtype thought to be responsible for the bulk of the glutamate uptake in forebrain regions. A complete elucidation of the functional role of EAAT-2 has been hampered by the lack of potent and selective pharmacological tools. In this study, we describe the synthesis and biological activities of novel aryl-ether, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of EAAT-2. Compound (16) represents one of the most potent (IC50 = 85 ± 5 nM) and selective inhibitors of EAAT-2 identified to date.
