300552-38-9

Usage

Uses

Used in Pharmaceutical Industry:
SPIRO[2H-1-BENZOPYRAN-2,4'-PIPERIDIN]-4(3H)-ONE, 6-CHLORO-, HYDROCHLORIDE is used as a potential anticancer agent for its cytotoxic effects against various cancer cell lines. Its development as a novel drug candidate for the treatment of cancer is warranted due to its promising therapeutic effects.
Used in Cancer Research:
In cancer research, SPIRO[2H-1-BENZOPYRAN-2,4'-PIPERIDIN]-4(3H)-ONE, 6-CHLORO-, HYDROCHLORIDE is utilized for further exploration in preclinical and clinical studies to evaluate its efficacy and safety as a potential anticancer agent. Its cytotoxic properties and improved solubility and stability in the hydrochloride salt form make it a valuable compound for cancer treatment research.

Upstream product

• 50893-53-3 carbonochloridic acid 1-chloro-ethyl ester 
• 81122-68-1 1'-benzyl-6-chlorospiro[chromene-2,4'-piperidin]-4(3H)-one 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 1011482-37-3 N-Boc-6-chlorospiro[chromene-2,4'-piperidin]-4(3H)-one 
• 1450-74-4 5-chloro-2-hydroxyacetophenone 

Relevant academic research and scientific papers

Design, Synthesis, and Structure-Activity Relationship of Novel Spiropyrimidinamines as Fungicides against Pseudoperonospora cubensis

Harmful fungus and the developed resistance to available fungicides seriously threaten the yield and quality of crops; thus, the search for new, highly efficient, and resistance-overcoming fungicides remains a quite urgent goal of agricultural scientists. In this study, a series of novel spiropyrimidinamine derivatives were designed and synthesized by employing the intermediate derivatization method (IDM). Their structures were identified by 1H NMR, elemental analyses, and MS spectra. The structure of compound 5 was further confirmed by X-ray diffraction. Bioassays indicated that a number of the title compounds exhibited some fungicidal activities against Pseudoperonospora cubensis. Especially, compound 5 displayed excellent activity (EC50 = 0.422 mg/L), significantly higher than those of the commercialized fungicides cyazofamid, flumorph, and diflumetorim. The structure-activity relationship was also discussed. It was concluded that compound 5 with super fungicidal potency and a novel structure is a promising agrochemical fungicide candidate for further development.

SPIROCHROMANE DERIVATIVES

The invention relates to spirochromane derivatives, or pharmaceutically acceptable salts, biologically active metabolites, pro-drugs, racemates, enantiomers, diastereomers, solvates and hydrates thereof, as well as to pharmaceutical compositions containin

Sorbitol dehydrogenase inhibitors

This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, wherein R1, R2and R3are as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds and methods of treating or preventing diabetic complications, particularly diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, diabetic macroangiopathy and diabetic cardiomyopathy by administering such compounds to a mammal suffering from diabetes and therefore at risk for developing such complications. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an aldose reductase inhibitor and to methods of treating or preventing diabetic complications therewith. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an NHE-1 inhibitor and to methods of treating cardiomyopathy and other heart-related problems therewith. This invention is also directed to certain intermediates used in the synthesis of the compounds of formula I and to processes for preparing those intermediates.