30062-44-3

Usage

Uses

Used in Pharmaceutical Industry:
5-Allylsulfanyl-[1,3,4]thiadiazol-2-ylamine is used as a pharmaceutical agent for its antimicrobial properties, helping to combat various types of infections caused by bacteria.
Used in Antifungal Applications:
In the field of antifungal treatment, 5-Allylsulfanyl-[1,3,4]thiadiazol-2-ylamine serves as an agent to treat fungal infections, providing an alternative for managing such conditions.
Used in Anti-inflammatory Applications:
5-Allylsulfanyl-[1,3,4]thiadiazol-2-ylamine is utilized as an anti-inflammatory agent, potentially aiding in the reduction of inflammation and associated symptoms.
Used in Antitumor and Anti-cancer Research:
In the area of oncology, 5-Allylsulfanyl-[1,3,4]thiadiazol-2-ylamine and its derivatives are used as research compounds for their potential anti-tumor and anti-cancer properties, offering new avenues for cancer treatment and therapy development.

InChI:InChI=1/C5H7N3S2/c1-2-3-9-5-8-7-4(6)10-5/h2H,1,3H2,(H2,6,7)

Upstream product

• 2349-67-9 2-Amino-5-mercapto-1,3,4-thiadiazole 
• 106-95-6 allyl bromide 
• 107-05-1 3-chloroprop-1-ene 

Downstream Products

• 69395-64-8 2-allylsulfanyl-[1,3,4]thiadiazolo[3,2-a]pyrimidine-5,7-dione 
• 69395-67-1 2-allylsulfanyl-6-benzyl-[1,3,4]thiadiazolo[3,2-a]pyrimidine-5,7-dione 
• 54508-95-1 (5-allylsulfanyl-[1,3,4]thiadiazol-2-yl)-dithiocarbamic acid benzyl ester 
• 70863-54-6 2-allylsulfanyl-6-phenylimidazo[2,1-b][1,3,4]thiadiazole 

Relevant academic research and scientific papers

Crystal structure of an AgClO4 π complex with 2-amino-5-allylthio-1,3,4-thiadiazole of the composition [Ag(C5H7N3S2)(ClO4)]

By interaction of AgClO4 with 2-amino-5-allylthio-1,3,4-thiadiazole (Aаtd) in the ethanol solution, a new [Ag(Aаtd)(ClO4)] π complex is obtained. It is studied by single crystal X-ray diffraction.

Synthesis, structure and computational study of 5-[(prop-2-en-1-yl)sulfanyl]-1,3,4-Thiadiazol-2-amine (Pesta) and its heterometallic p,r-complex [Cu2FeCl2(Pesta)4][FeCl4]

Copper(I) π-coordination compounds with allyl derivatives of azoles are an interesting subject of current research, but CuI π-complexes with other transition-metal ions incorporated in the structure have been virtually uninvestigated. The present work is directed toward the synthesis and structural characterization of the novel heterometallic CuI/FeII π-complex di-μ2-chlorido-1:2κ2 Cl;2:3κ2 Cl-Tetrakis[μ2-5-(prop-2-en-1-ylsulfanyl)-1,3,4-Thiadiazol-2-Amine]-1:2κ2 N 4:N 3;1(η2),κN 4:2κN 3;2:3κ2 N 3:N 4;2κN 3:3(η2),κN 4-dicopper(I)iron(II) tetrachloridoferrate(II), [Cu2FeCl2(C5H7N3S2)4][FeCl4] (1). The structure of the 5-[(prop-2-en-1-yl)sulfanyl]-1,3,4-Thiadiazol-2-Amine (Pesta, C5H7N3S2) ligand is also presented. The cationic substructure in 1 consists of one FeII and two CuI ions bridged by two chloride ions along with two σ,σ-and two π,σ-coordinated ligands, whereas the anionic part is built of isolated tetrahedral [FeCl4]2- ions. π-Coordination of the Pesta allyl group to the CuI ions prevents agglomeration of the inorganic Cu-Cl-Fe-Cl-Cu part into infinate chains. An energy framework computational analysis was performed for Pesta.

Design and development of 1,3,4-thiadiazole based potent new nano-fungicides

Being the important organic reaction intermediates and biological scaffolds, a series of 2-alkyl/aralkyl/heterocyclyl sulfanyl-5-amino/methyl-1,3,4-thiadiazoles have been synthesized by suitable synthetic route and characterized by analytical and spectral data. The evaluation of these compounds for their bioefficacy against two phyto-pathogenic fungi revealed their fungicidal potency against Rhizoctonia bataticola (ED50 values, 3.9–300.4 μg/mL) and Rhizoctonia solani (ED50 values, 4.2–228.5 μg/mL). To further augment their fungicidal efficacy, the potent five fungicidal compounds were nano-sized. The protocol for preparing 1,3,4-thiadiazole based nano-fungicide employing polyethylene glycol was developed and standardized. Characterization of nano-forms of 1,3,4-thiadiazole derivatives by particle size analyzer and electron microscopy (TEM) techniques confirmed the 100 nm average particle sizes of all nano-fungicides. The 2–4 times higher fungicidal activity was observed with nano-forms than the corresponding conventional sized 1,3,4-thiadiazole derivatives against phytopathogenic fungi, namely, Rhizoctonia solani and R. bataticola.

Synthesis of 2-alkyl/arylalkyl/phenacylsul-fanyl-1 -thia-3,3, 10-triaza-pentaleno[ 1,2-b]naphthalene-4,9-dione

2,3-Dichloronaphthoquinone is condensed with 5-(alkyl/arylalkyl/ phenacylthio)-1,3,4-thiadiazol-2-amine in acetic acid to furnish a novel and hitherto unknown 2-alkyl/aralkyl/phenacylsulfanyl-1-thia-3,3a,10-triaza- pentaleno[1,2-b]naphthalene-4,9-dione. The structure of the synthesized compound has been confirmed by converting it into the corresponding reductive acetate. The structures of newly prepared compounds have been confirmed by analytical and spectral data.