30094-77-0Relevant articles and documents
Oxygen-involved oxidative deacetylation of α-substituted β-acetyl amides - Synthesis of α-Keto amides
Li, Dianjun,Yu, Wei
supporting information, p. 3708 - 3714 (2014/01/06)
α-Substituted β-acetyl amides could undergo C-C bond cleavage to form α-keto amides when treated with copper(II) chloride (CuCl 2) and boron trifluoride diethyl etherate (BF3× OEt2) under an oxygen atmosphere. The yield can be increased by the addition of tert-butyl hydroperoxide which alone can also effect the reaction. The reaction provides a new protocol for the synthesis of α-keto amides. Copyright