20717-39-9

Upstream product

• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 62-53-3 aniline 
• 29397-21-5 Diacetyldiazomethan 
• 74-83-9 methyl bromide 
• 102-01-2 N-phenylacetoacetamide 
• 87769-39-9 2,2,5,6-tetramethyl-2H,4H-1,3-dioxin-4-one 
• 74-88-4 methyl iodide 
• 132723-21-8 2-Methyl-1-butene-1,3-dione 

Downstream Products

• 17336-90-2 3,4-Dimethyl-carbostyril 
• 28252-07-5 2,2-dimethyl-3-oxo -N-phenylbutanamide 
• 52629-27-3 1,2-Dimethyl-3-phenylimino-2-propen-1-on 
• 90033-14-0 (+/-)-(2S,3R)-3-hydroxy-2-methyl-N-phenylbutanamide 
• 90033-14-0 (+/-)-(2S,3S)-3-hydroxy-2-methyl-N-phenylbutanamide 
• 102998-86-7 γ-Brom-α-methyl-acetessigsaeureanilid 
• 127603-88-7 3-Hydroxy-2-methyl-N-phenyl-butyramide 
• 87568-36-3 (+/-)-1-phenyl-3β,4β-dimethylazetidin-2-one 
• 83375-57-9 (3R,4R)-3,4-Dimethyl-1-phenyl-azetidin-2-one 
• 127603-98-9 Methanesulfonic acid (1R,2S)-1-methyl-2-phenylcarbamoyl-propyl ester 
• 127603-98-9 Methanesulfonic acid (1R,2R)-1-methyl-2-phenylcarbamoyl-propyl ester 
• 139192-32-8 3-(3-Phenyl-5-trimethylsilanyl-3H-[1,2,3]triazol-4-yl)-butan-2-one 
• 1006375-66-1 4-bromo-5-methyl-6-oxo-1-phenyl-1,6-dihydropyridine-3-carbaldehyde 
• 1006375-86-5 4-chloro-5-methyl-6-oxo-1-phenyl-1,6-dihydropyridine-3-carbaldehyde 

Relevant academic research and scientific papers

Enantioselective α-Amination of Acyclic 1,3-Dicarbonyls Catalyzed by N-Heterocyclic Carbene

Herein, we describe a method for the catalytic enantioselective α-amination of α-substituted acyclic 1,3-ketoamides and 1,3-amidoesters that affords the products possessing N-substituted quaternary stereocenters with a chiral N-heterocyclic carbene (NHC). The reaction is based on the utilization of an intrinsic Br?nsted base characteristic of NHC that enables the catalytic formation of a chiral ion pair comprising the enolate and the azolium ion. A series of challenging open-chain α-substituted 1,3-dicarbonyls are aminated via this method with ee's of ≤99%.

A facile and efficient synthesis of polyfunctionalized pyridin-2(1H)-ones from β-oxo amides under Vilsmeier conditions

(Chemical Equation Presented) A facile and efficient one-pot synthesis of polysubstituted pyridin-2(1H)-ones from a variety of β-oxo amides under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation and intramo

Reaction of lithium trimethylsilyldiazomethanide with ketenimines bearing electron-withdrawing groups

Ketenimines bearing electron-withdrawing groups (X in 1) at the C2-position react with lithium trimethylsilyldiazomethanide [diazo(lithio)trimethylsilylmethane] to give 4-amino-3-trimethylsilylpyrazoles 4 or 5 mainly; in some cases 4-trimethylsilyl-1,2,3-triazole derivatives 3 were formed as the major products.

Synthesis of β-Ketocarboxamide Derivatives Using 2,2-Dimethyl-2H,4H-1,3-dioxin-4-ones

Thermal reaction of 2,2-dimethyl-2H,4H-1,3-dioxin-4-ones (1) with amines was studied.Acylketenes 2, generated by heating of 1, reacted with anilines and benzylamine to give the corresponding β-ketocarboxamides (3,4, and 5) in good yields.The reaction of 1 with ammonia gave 3-amino-2-alkenamides (7), which were hydrolyzed to β-ketocarboxamides (6).The former products 7 were readily transformed to the 6-substituted 2-methyl-3H-pyrimidin-4-ones (9) via the 3-acetamido-2-alkenamides (8).Acylation of O-benzylhydroxylamine with 1 gave the β-ketohydroxamic acids 10.Debenzylation of 10 followed by cyclization gave rise to 5-alkyl-3-hydroxyisoxazoles (12).The reaction of 1 with amides gave the corresponding N-acetylated amides (13). Keywords --- 2H,4H-1,3-dioxin-4-one; thermal fragmentation; acylketene; acylation; carboxamide; hydroxamic acid; 3-hydroxyisoxazole; 3H-pyrimidin-4-one