301206-01-9

Basic information

• Product Name: Benzamide, 4-(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-3,5-dimethyl-
• Synonyms: Benzamide, 4-(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-3,5-dimethyl-
• CAS NO: 301206-01-9
• Molecular Formula: C22H22N4O5
• Molecular Weight: 422.43
• Mol File: 301206-01-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzamide, 4-(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-3,5-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 4-(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-3,5-dimethyl-(301206-01-9)
• EPA Substance Registry System: Benzamide, 4-(acetyloxy)-N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-3,5-dimethyl-(301206-01-9)

Safety Data

• Hazardous Substances Data: 301206-01-9(Hazardous Substances Data)

Upstream product

• 1007-36-9 1-methyl-3-phenylurea 
• 72702-74-0 N-cyanoacetyl-N-methyl-N'-phenyl-urea 
• 4919-37-3 3,5-dimethyl-4-hydroxybenzoic acid 
• 42212-19-1 6-amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)dione 
• 50786-93-1 5,6-diamino-3-methyl-1-phenyluracil 
• 23298-94-4 3,5-dimethyl-4-acetoxybenzoic acid 

Relevant articles and documents

Inhibitory activities of novel pyrimidine derivatives on the contact hypersensitivity reaction.

In order to obtain novel topically applied anti-inflammatory compounds containing an inexpensive anti-oxidative moiety without chirality, we synthesized compound 2c derivatives having a di-tert-butylphenol moiety, and evaluated by topical administration their anti-inflammatory potentials on picryl chloride-(PC) induced contact hypersensitivity reaction (CHR) in mice. In the course of our structure-activity relationship (SAR) studies on the pyrimidine or the anti-oxidative moiety and the linker between them, the most potent compounds (10, 11) were obtained by the insertion of a C2 unit in compound 2c. The potencies of these compounds were 2-fold greater than that of 1. Compounds 10 and 11 were considered to be useful lead compounds having inexpensive anti-oxidative moieties without chirality.