301206-98-4Relevant academic research and scientific papers
General Approach for the Liquid-Phase Fragment Synthesis of Orthogonally Protected Naturally Occurring Polyamines and Applications Thereof
Kalantzi, Stefania,Athanassopoulos, Constantinos M.,Ruonala, Raili,Helariutta, Yrjo,Papaioannou, Dionissios
, p. 15118 - 15130 (2019)
Orthogonally protected polyamines (PAs) have been synthesized using α,ω-diamines and ω-aminoalcohols as N-Cx-N and N-Cy synthons, respectively, and the Mitsunobu reaction as the key reaction for the assembly of the PA skeleta. The Trt, Dde, and Phth groups have been employed for protecting the primary amino functions and the Ns group for activating the primary amino functions toward alkylation and secondary amino function protection. The approach has been readily extended to accommodate the total synthesis of the spider toxins Agel 416 and HO-416b, incorporating the 3-4-3-3 and the 3-3-3-4 PA skeleton, respectively.
CXCR4-TARGETED DIAGNOSTIC AND THERAPEUTIC AGENTS WITH REDUCED SPECIES SELECTIVITY
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Page/Page column 47; 50-51, (2020/05/07)
The present disclosure relates to imaging and endoradiotherapy of diseases involving chemokine receptor 4 (CXCR4). Provided are compounds which bind or inhibit hCXCR4 and mCXCR4 and furthermore carry at least one moiety which is amenable to labeling. Provided are also medical uses of such compounds.
Solid-phase synthesis of Agel 416; a novel approach to modified polyamines
Hone,Payne
, p. 6149 - 6152 (2007/10/03)
The synthesis of Agel 416, an acylpolyamine derived from the Spider Agenolopsis aperta, has been achieved on solid support. Stepwise synthesis of the polyamine chain was accomplished using N-protected amino alcohols and the Fukuyama-Mitsunobu reaction. (C) 2000 Published by Elsevier Science Ltd.
