301308-88-3

Basic information

• Product Name: N-(4-ethylphenyl)methanesulfonamide
• Synonyms: N-(4-ethylphenyl)methanesulfonamide
• CAS NO: 301308-88-3
• Molecular Formula: C₉H₁₃NO₂S
• Molecular Weight: 199.27002
• Mol File: 301308-88-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-ethylphenyl)methanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-ethylphenyl)methanesulfonamide(301308-88-3)
• EPA Substance Registry System: N-(4-ethylphenyl)methanesulfonamide(301308-88-3)

Safety Data

• Hazardous Substances Data: 301308-88-3(Hazardous Substances Data)

Upstream product

• 97-94-9 triethyl borane 
• 4284-50-8 N-(4-bromophenyl)methanesulfonamide 
• 124-63-0 methanesulfonyl chloride 
• 589-16-2 4-aminoethylbenzene 

Downstream Products

• 1188925-35-0 N-(4-ethyl-4-methoxycyclohexa-2,5-dien-1-ylidene)methanesulfonamide 

Relevant articles and documents

Soft-Hard Acid/Base-Controlled, Oxidative, N-Selective Arylation of Sulfonanilides via a Nitrenium Ion

In iodine(III)-catalyzed, dehydrogenative arylations of sulfonanilides, the functionalization of C-C bonds is preferred over the functionalization of C-N bonds. Herein, an unprecedented N-selective arylation of sulfonanilides using soft-hard acid-base (SHAB) control by a nitrenium ion over a carbenium ion is reported. Treatment of sulfonanilides with iodine(III) led to the formation of nitrenium ions (soft), which preferentially react with biphenyls (soft) over bimesityl (hard) to generate C-N bonds. The iodine(III) was generated in situ by using PhI and mCPBA at room temperature.

B-Alkyl Suzuki-Miyaura cross-coupling of tri-n-alkylboranes with arylbromides bearing acidic functions under mild non-aqueous conditions

An efficient and chemoselective Pd-catalyzed B-alkyl Suzuki-Miyaura cross-coupling of tri-n-alkylboranes with arylbromides possessing acidic functions is described. This protocol features the relatively weak base Cs2CO3 and mild non-