30148-25-5Relevant academic research and scientific papers
Base-Promoted Amidation and Esterification of Imidazolium Salts via Acyl C-C bond Cleavage: Access to Aromatic Amides and Esters
Karthik, Shanmugam,Muthuvel, Karthick,Gandhi, Thirumanavelan
supporting information, p. 738 - 751 (2019/01/24)
Imidazolium salts have been effectively employed as suitable acyl transfer agents in amidation and esterification in organic synthesis. The weak acyl C(O)-C imidazolium bond was exploited to generate acyl electrophiles, which further react with amines and alcohols to afford amides and esters. The broad substrate scope of anilines and benzylic amines and base-promoted conditions are the benefits of this route. Interestingly, phenol, benzylic alcohols, and a biologically active alcohol can also be subjected to esterification under the optimized conditions.
Synthesis of 2-aroyl-1-methyl-1H-imidazoles using aryl carboxylic acids
Oyama, Kin-ichi,Watanabe, Noriyuki,Yoshida, Kumi
, p. 1177 - 1183 (2019/12/11)
A new and useful reaction for the synthesis of 2-aroyl-1-methyl-1H-imidazoles using free aryl carboxylic acids was developed. This method was applicable to naphthoic acid and benzoic acid derivatives to give each target compound with up to 80% yield.
