30149-93-0

Usage

Uses

Used in Pharmaceutical Development:
3-[3-(4-CHLOROPHENYL)-1,2,4-OXADIAZOL-5-YL]PROPANOIC ACID is used as a potential pharmaceutical candidate for the development of new drugs, leveraging its diverse pharmacological properties and potential therapeutic applications.
Used in Medicinal Chemistry Research:
3-[3-(4-CHLOROPHENYL)-1,2,4-OXADIAZOL-5-YL]PROPANOIC ACID serves as a valuable research tool in medicinal chemistry, enabling scientists to explore its specific biological activities and investigate its potential as a lead compound for drug discovery.
Used in Antimicrobial Applications:
In the field of antimicrobial research, 3-[3-(4-CHLOROPHENYL)-1,2,4-OXADIAZOL-5-YL]PROPANOIC ACID is used as an active agent to combat various microorganisms, given its potential antimicrobial properties.
Used in Antifungal Applications:
3-[3-(4-CHLOROPHENYL)-1,2,4-OXADIAZOL-5-YL]PROPANOIC ACID is utilized as an antifungal agent, targeting fungal infections and contributing to the development of novel antifungal therapies.
Used in Anti-inflammatory Applications:
In the realm of anti-inflammatory research, 3-[3-(4-CHLOROPHENYL)-1,2,4-OXADIAZOL-5-YL]PROPANOIC ACID is employed as a potential agent to alleviate inflammation and reduce associated symptoms.
Used in Anticancer Applications:
3-[3-(4-CHLOROPHENYL)-1,2,4-OXADIAZOL-5-YL]PROPANOIC ACID is explored as an anticancer agent, with potential to target and inhibit the growth of cancer cells, contributing to the advancement of cancer treatment options.

InChI:InChI=1/C11H9ClN2O3/c12-8-3-1-7(2-4-8)11-13-9(17-14-11)5-6-10(15)16/h1-4H,5-6H2,(H,15,16)/p-1

Upstream product

• 108-30-5 succinic acid anhydride 
• 5033-28-3 4-chloro-N'-hydroxybenzimidamide 
• 623-03-0 4-Cyanochlorobenzene 
• 5033-28-3 4-chlorobenzamidoxime 

Downstream Products

• 1187182-75-7 3-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]propionic acid prop-2-ynyl ester 

Relevant academic research and scientific papers

Development of fluorinated CB2 receptor agonists for PET studies

A convergent strategy was followed to modify systematically carbazole based CB2 receptor ligands. The length of the N-(fluoroalkyl) group (n in 7), the length of the alkanamide (m in 7) and the substitution pattern of the phenyl moiety (X and Y in 7) were varied systematically. The highest CB 2 affinity was found for the 2-fluoroethyl substituted carbazole derivative 20a (Ki = 5.8 nM) containing the propionamide and the 2-bromo-4-fluorophenyl moiety. According to docking studies 20a fits nicely into the binding pocket of the CB2 receptor, but elongation of the fluoroethyl side chain leads to a different binding mode of the ligands. The high CB2 affinity together with the high selectivity over the CB 2 subtype qualifies the fluoroethyl derivative 20a to be developed as a PET tracer.

Improved microwave-mediated synthesis of 3-(3-aryl-1,2,4-oxadiazol-5-yl) propionic acids and their larvicidal and fungal growth inhibitory properties

The synthesis of 3-(3-aryl-1,2,4-oxadiazol-5-yl)propionic acids from arylamidoximes and succinic anhydride under focused microwave irradiation conditions is described. The new synthetic method furnished the desired products in 2-3 min and good yields. Fur

Synthesis and structure determination of N,N-diethyl-3-[3-aryl-1,2,4- oxadiazol-5-yl]propionamides

An efficient and facile synthesis of six new 1,2,4-oxadiazoles (6a-f) with a tertiary amide group attached on the side-chain, in high yield, is described. Correct assignments of side-chain methylene, methyl protons, and carbon signals have been made with the assistance of COSY, NOESY and HETCOR NMR experiments.