301542-57-4Relevant articles and documents
2-AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS
-
Page/Page column 46, (2009/07/03)
Provided are compounds of formula I that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes meilitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.
Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 2: (3-substituted-5-halo-2-pyridinyl)guanidines
Barber, Christopher G.,Dickinson, Roger P.
, p. 185 - 187 (2007/10/03)
Based on previous modeling predictions, a series of (3-substituted-5-chloro-2-pyridinyl)guanidines have been designed with good potency and selectivity for urokinase-type plasminogen activator (uPA). Compound 36 has a Ki of 0.17 μM and greater than 300-fold selectivity with respect to tPA and plasmin.