3016-20-4Relevant academic research and scientific papers
Application of monocarbonyl curcumin compound in preparation of medicine for preventing and treating periodontitis
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Paragraph 0024-0026; 0039, (2021/06/22)
The invention belongs to the technical field of medicines, and particularly relates to application of a specific monocarbonyl curcumin analogue in preparation of a medicine for preventing and treating periodontitis. Experiments prove that the monocarbonyl curcumin analogues not only can play a better anti-oxidation protection role by activating an Nrf2/HO-1 signal channel, but also can play an anti-inflammatory role by inhibiting release of inflammatory factors TNF alpha and IL1-beta, so that the monocarbonyl curcumin analogues have a remarkable prevention and treatment effect on rat periodontitis, have good potential value and significance for prevention and treatment of periodontitis, and have a good research and development prospect.
The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones
Pati, Hari N.,Das, Umashankar,Das, Swagatika,Bandy, Brian,De Clercq, Erik,Balzarini, Jan,Kawase, Masami,Sakagami, Hiroshi,Quail, J. Wilson,Stables, James P.,Dimmock, Jonathan R.
experimental part, p. 54 - 62 (2009/04/07)
This study demonstrated that replacement of the axial protons on the C2 and C6 atoms of various 1-methyl-3,5-bis(benzylidene)-4-piperidones 3 by a dimethylene bridge leading to series 2 lowered cytotoxic potencies. Four compounds 2a and 3a-c emerged as lead molecules based on their toxicity towards different neoplasms and their selective toxicity for malignant rather than normal cells. Some possible reasons for the disparity between the IC50 values in the two series of compounds are presented based on molecular modeling, log P values and respiration in rat liver mitochondria.
The preparation of 2-arylmethylidene-8-methyl-8-azabicyclo[3.2.1]octan-3- ones
Zheng, Guangrong,Dwoskin, Linda P.,Crooks, Peter A.
, p. 1931 - 1942 (2007/10/03)
An efficient and versatile two-step synthesis of 2-arylmethylidene-8- methyl-8-azabicyclo[3.2.1]octane-3-ones, via mono aldol condensation of tropinone with a variety of aryl aldehydes followed by pTsOH-catalyzed dehydration, is described.
Synthesis of 2,4-disubstituted nortropinone derivatives by aldol condensation
Jung,Park,Kim,Lee,Lee,Park,Choi
, p. 3255 - 3263 (2007/10/03)
2,4-Disubstituted nortropinone derivatives 2, with anticipated anticonvulsant activity, were synthesized by the reaction of N-substituted nortropinones, ethanol, 5N-NaOH, and aromatic aldehydes (R1CHO).
