301699-00-3

Usage

Uses

Used in Food Industry:
2,2-dimethyl-5-4-(methylsulfinyl)phenyl-3(2H)furanone is used as a flavoring agent for its distinctive caramel and maple syrup-like aroma, enhancing the taste and appeal of various dishes and beverages.
Used in Aromatherapy and Fragrance Industry:
Although not explicitly mentioned in the provided materials, due to its strong and pleasant odor, Sotolone could potentially be used in the creation of perfumes, colognes, and other fragrances to provide a unique and attractive scent profile.
Used in Pharmaceutical Research:
2,2-dimethyl-5-4-(methylsulfinyl)phenyl-3(2H)furanone is studied for its potential therapeutic effects, such as anti-inflammatory and antioxidant properties. It is used in research as a candidate for developing new medications, pending further investigation into its medicinal properties.

Upstream product

• 301698-95-3 2,2-dimethyl-5-(4-(methylthio)phenyl)-3(2H)furanone 
• 301698-94-2 1-{4-(methylthio)phenyl}-4-hydroxy-4-methyl-2-pentyn-1-one 
• 301698-93-1 1-{4-(methylthio)phenyl}-4-hydroxy-4-methyl-2-pentyn-1-ol 
• 3446-89-7 4-(Methylthio)benzaldehyde 
• 115-19-5 2-methyl-but-3-yn-2-ol 

Downstream Products

• 301699-01-4 2,2-dimethyl-4-iodo-5-{4-(methylsulfinyl)phenyl}-3(2H)furanone 
• 301699-02-5 5-{4-(aminosulfonyl)phenyl}-2,2-dimethyl-4-iodo-3(2H)furanone 
• 301692-84-2 5-{4-(Aminosulfonyl)phenyl}-2,2-dimethyl-4-phenyl-3(2H)-furanone 
• 301692-70-6 5-{4-(Aminosulfonyl)phenyl}-4-(3-chlorophenyl)-2,2-dimethyl-3(2H)-furanone 
• 301692-76-2 polemacoxib 
• 301692-94-4 5-{4-(Aminosulfonyl)phenyl}-4-(3,4-difluorophenyl)-2,2-dimethyl-3(2H)-furanone 
• 301699-28-5 4-bromo-2,2-dimethyl-5-{4-(methylsulfinyl)phenyl}-3(2H)-furanone 

Relevant academic research and scientific papers

In Vitro Structure-Activity Relationship and in Vivo Studies for a Novel Class of Cyclooxygenase-2 Inhibitors: 5-Aryl-2,2-dialkyl-4-phenyl-3(2H)furanone Derivatives

5-Aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives were studied as a novel class of selective cyclooxygenase-2 inhibitors with regard to synthesis, in vitro SAR, antiinflammatory activities, pharmacokinetic considerations, and gastric safety. If, a representative compound for methyl sulfone derivatives, showed a COX-2 IC50 comparable to that of rofecoxib. In case of 20b, a representative compound for sulfonamide derivatives, a potent antiinflammatory ED50 of 0.1 mg kg-1 day-1 was observed against adjuvant-induced arthritis by a preventive model, positioning 20b as one of the most potent COX-2 inhibitors ever reported. Furthermore, 20b showed strong analgesic activity as indicated by its ED50 of 0.25 mg/kg against carrageenan-induced thermal hyperalgesia in the Sprague-Dawley rat. 3(2H)Furanone derivatives showed due gastric safety profiles as selective COX-2 inhibitors upon 7-day repeat dosing. A highly potent COX-2 inhibitor of the 3(2H)furanone scaffold could be considered suitable for a future generation COX-2 selective arthritis medication with improved safety profiles.

4,5-diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors

The present invention provides a novel class of 4,5-diaryl-3(2H)-furanone derivatives, which inhibit strongly and selectively COX-2 over COX-1. They are useful to treat inflammation, inflammation-associated disorders, and COX-2 mediated diseases.