301698-95-3

Usage

Uses

Used in Food Industry:
Raspberry ketone is used as a flavoring agent in the food industry to impart a fruity aroma and taste to various food products. Its natural occurrence and pleasant flavor profile make it a popular choice for enhancing the sensory experience of food items.
Used in Cosmetic Industry:
In the cosmetic industry, raspberry ketone is utilized for its aromatic properties, adding a fresh and fruity scent to various cosmetic products such as perfumes, lotions, and creams.
Used in Perfumery:
Raspberry ketone is employed in the production of perfumes due to its unique and appealing fruity aroma. It contributes to the overall scent profile of perfumes, providing a natural and refreshing note.
Used in Weight Management:
Although research is limited, raspberry ketone has been studied for its potential health benefits, including its ability to aid in weight loss. It is believed to influence metabolic function, which may contribute to weight management. However, further studies are needed to confirm its effectiveness and safety in this application.
Used in Metabolic Function Improvement:
Raspberry ketone has also been investigated for its potential to improve metabolic function. Its effects on metabolism may have implications for overall health and well-being, but more research is required to fully understand its impact and establish its use in this context.

Upstream product

• 109-89-7 diethylamine 
• 301698-94-2 1-{4-(methylthio)phenyl}-4-hydroxy-4-methyl-2-pentyn-1-one 
• 301698-93-1 1-{4-(methylthio)phenyl}-4-hydroxy-4-methyl-2-pentyn-1-ol 
• 3446-89-7 4-(Methylthio)benzaldehyde 
• 115-19-5 2-methyl-but-3-yn-2-ol 

Downstream Products

• 301698-96-4 4-bromo-2,2-dimethyl-5-{4-(methylthio)phenyl}-3(2H)furanone 
• 301698-97-5 4-bromo-2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-3(2H)furanone 
• 301691-41-8 4-(3-Chlorophenyl)-2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-3(2H)-furanone 
• 301691-67-8 4-(3,5-Dichlorophenyl)-2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-3(2H)-furanone 
• 301699-01-4 2,2-dimethyl-4-iodo-5-{4-(methylsulfinyl)phenyl}-3(2H)furanone 
• 301699-02-5 5-{4-(aminosulfonyl)phenyl}-2,2-dimethyl-4-iodo-3(2H)furanone 
• 301692-84-2 5-{4-(Aminosulfonyl)phenyl}-2,2-dimethyl-4-phenyl-3(2H)-furanone 
• 301691-73-6 4-(4-Bromophenyl)-2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-3(2H)-furanone 
• 301692-07-9 2,2-Dimethyl-4-(3-methoxyphenyl)-5-{4-(methylsulfonyl)phenyl}-3(2H)-furanone 
• 301692-70-6 5-{4-(Aminosulfonyl)phenyl}-4-(3-chlorophenyl)-2,2-dimethyl-3(2H)-furanone 

Relevant academic research and scientific papers

In Vitro Structure-Activity Relationship and in Vivo Studies for a Novel Class of Cyclooxygenase-2 Inhibitors: 5-Aryl-2,2-dialkyl-4-phenyl-3(2H)furanone Derivatives

5-Aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives were studied as a novel class of selective cyclooxygenase-2 inhibitors with regard to synthesis, in vitro SAR, antiinflammatory activities, pharmacokinetic considerations, and gastric safety. If, a representative compound for methyl sulfone derivatives, showed a COX-2 IC50 comparable to that of rofecoxib. In case of 20b, a representative compound for sulfonamide derivatives, a potent antiinflammatory ED50 of 0.1 mg kg-1 day-1 was observed against adjuvant-induced arthritis by a preventive model, positioning 20b as one of the most potent COX-2 inhibitors ever reported. Furthermore, 20b showed strong analgesic activity as indicated by its ED50 of 0.25 mg/kg against carrageenan-induced thermal hyperalgesia in the Sprague-Dawley rat. 3(2H)Furanone derivatives showed due gastric safety profiles as selective COX-2 inhibitors upon 7-day repeat dosing. A highly potent COX-2 inhibitor of the 3(2H)furanone scaffold could be considered suitable for a future generation COX-2 selective arthritis medication with improved safety profiles.

4,5-diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors

The present invention provides a novel class of 4,5-diaryl-3(2H)-furanone derivatives, which inhibit strongly and selectively COX-2 over COX-1. They are useful to treat inflammation, inflammation-associated disorders, and COX-2 mediated diseases.

2,2-dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors

A series of 2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-4-phenyl-3(2H)furanones was prepared and evaluated for their ability to inhibit cyclo-oxygenase-2 (COX-2).