301851-37-6Relevant articles and documents
A symmetry-based formal synthesis of zaragozic acid A
Freeman-Cook, Kevin D.,Halcomb, Randall L.
, p. 6153 - 6159 (2007/10/03)
A symmetry-based strategy for the synthesis of the zaragozic acids is reported. Two enantioselective dihydroxylations were used to establish the absolute configuration of a C2 symmetric intermediate. Noteworthy transformations include a group-selective lactonization, which accomplished an end-differentiation of a pseudo-C2 symmetric intermediate. Late stage protecting group adjustments and oxidations accomplished a formal synthesis of zaragozic acid A.