30197-58-1Relevant academic research and scientific papers
Cycloalkyl and heterocycloalkyl inhibitors as well as preparation method and application thereof
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Paragraph 0295-0298, (2021/04/26)
The invention relates to cycloalkyl and heterocycloalkyl inhibitors as well as a preparation method and application thereof. Specifically, the compounds disclosed by the invention have a structure as shown in a formula (I). The invention also discloses a preparation method of the compounds and application of the compounds as KRASG12C inhibitors. The compounds have a good selective inhibition effect on KRASG12C, and have better pharmacodynamic and pharmacokinetic properties and lower toxic and side effects.
