556025-92-4

Upstream product

• 186581-53-3 diazomethane 
• 30216-57-0 1,3-thiazole-2-carbonyl chloride 
• 60-29-7 diethyl ether 
• 79265-30-8 2-(trimethylsilyl)thiazole 
• 79-04-9 chloroacetyl chloride 
• 24295-03-2 2-Acetylthiazole 
• 556025-90-2 [[1-(2-thiazolyl)ethenyl]oxy]tri-isopropylsilane 
• 556025-91-3 [[2-chloro-1-(2-thiazolyl)ethenyl]oxy]tri-isopropylsilane 

Downstream Products

• 943969-31-1 2-(1-hydroxy-2-chloroethyl)-thiazole 
• 1001014-48-7 5-(2-(4-iodophenyl)-4-(thiophen-2-yl)-1H-imidazol-1-yl)-2-methylpyridine 
• 562101-31-9 R-2-(1-hydroxy-2-N-methylamino-ethyl)-thiazole 

Relevant academic research and scientific papers

PESTICIDAL COMPOUNDS

A method of combating and controlling insects, acarines, nematodes or molluscs which comprises applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effect

Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease

To develop novel neuroprotective agents, a library of novel arylalkenylpropargylamines was synthesized and tested for inhibitory activities against monoamine oxidases. From this, a number of highly potent and selective monoamine oxidase B inhibitors were identified. Selected compounds were also tested for neuroprotection in in vitro studies with PC-12 cells treated with 6-OHDA and rotenone, respectively. It was observed that some of the compounds tested yielded a marked increase in survival in PC-12 cells treated with the neurotoxins. This indicates that these propargylamines are able to confer protection against the effects of the toxins and may also be considered as novel disease-modifying anti-Parkinsonian agents, which are much needed for the therapy of Parkinson's disease.

Solvent and in situ catalyst preparation impacts upon Noyori reductions of aryl-chloromethyl ketones: application to syntheses of chiral 2-amino-1-aryl-ethanols

As part of medicinal chemistry efforts we found it necessary to develop general syntheses of highly enantiomerically enriched 1-aryl-2-chloroethanols and 1-aryl-2-methylaminoethanols. A survey of literature methods suggested that a truly general approach had not yet been reported, encouraging us to undertake the development of such a methodology. This study describes the design, development, and reduction to practice of a general synthesis of chiral 1-aryl-2-chloroethanols and the transformation of these entities to highly enantiomerically enriched 1-aryl-2-methylaminoethanols. Of particular importance were observations of the impact of solvent and the method of catalyst preparation on the yield and enantiomerical excess of chlorohydrins prepared via Noyori transfer hydrogenations of aryl-chloromethyl ketones.

HETEROARYL-ETHANOLAMINE DERIVATIVES AS ANTIVIRAL AGENTS

The present invention provides a compound of formula as described herein, which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.

Pyridoquinoxaline antivirals

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein R1, R2 and R3 are as defined in the specification. The compounds are useful for the treatment of viral infections.