302346-90-3

Upstream product

• 93-97-0 benzoic acid anhydride 
• 58479-65-5 5'-O-(tert-butyldiphenylsilyl)cytidine 
• 65-46-3 CYTIDINE 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 302346-93-6 3-propenyl (2',3'-O,N⁴-tribenzoyl cytidine-5')-yl (methyl (5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-thio-β-D-glycero-D-galacto-2-nonulopyranosid-2))-yl phosphorothioate 
• 302346-91-4 3-propenyl-(2',3'-O,N⁴-tribenzoyl cytidine-5')-yl-N,N'-diisopropylphosphoramidite 
• 54898-05-4 N,2',3'-O-tribenzoylcytidine 

Relevant academic research and scientific papers

Selective inhibitors of bacterial phosphopantothenoylcysteine synthetase

(Figure Presented) Bacterial phosphopantothenolycysteine synthetase (PPCS) catalyzes the formation of phosphopantothenoylcysteine (PPC) from (R)-phosphopantothenate, L-cysteine, and cytidine-5′-triphosphate (CTP) and has been shown to be essential for gro

Synthesis and Characterization of an Anomeric Sulfur Analogue of CMP-Sialic Acid

α-2,3-Sialyltransferase catalyzes the transfer of sialic acid from CMP-sialic acid (1) to a lactose acceptor. An analogue of 1 was synthesized in which the anomeric oxygen atom was replaced with a sulfur atom (1S). The key step in the synthesis of IS was a tetrazole-promoted coupling of a cytidine-5′-phosphoramidite with a glycosyl thiol of a protected sialic acid. Compounds 1 and 1S were characterized for their activity in a sialyl transfer assay. The rate of solvolysis in aqueous buffer of analogue 1S was 50-fold slower than that of 1. Analogue 1S was found to be substrate for α-2,3-sialyltransferase. The Km of 1S was just 3-fold higher than that of 1, while the kcat of 1S was 2 orders of magnitude lower compared to 1.