302354-75-2Relevant academic research and scientific papers
Alkylation of nonstabilized aziridinylmagnesiums catalyzed by Cu(I) iodide: A new synthesis of amines, including optically active form, bearing a quaternary chiral center
Satoh,Matsue,Fujii,Morikawa
, p. 6495 - 6499 (2000)
A high-yield alkylation of aziridinylmagnesiums, which were generated from sulfinylaziridines with EtMgBr by sulfoxide-magnesium exchange, with primary alkyl halides in the presence of Cu(I) iodide as a catalyst, was realized. The alkylated aziridines were converted in quantitative yield to amines bearing a quaternary chiral center by hydrogenation with Pd(OH)2. A synthesis of the optically active amines, bearing a quaternary chiral center, was realized, starting from optically active (R)-chloromethyl p-tolyl sulfoxide, in good overall yield by the presented method. (C) 2000 Elsevier Science Ltd.
