302567-98-2

Basic information

• Product Name: Carbamic acid, (4-methoxyphenyl)-, 9H-fluoren-9-ylmethyl ester (9CI)
• Synonyms: Carbamic acid, (4-methoxyphenyl)-, 9H-fluoren-9-ylmethyl ester (9CI)
• CAS NO: 302567-98-2
• Molecular Formula: C22H19NO3
• Molecular Weight: 345.39116
• Product Categories: FMOC
• Mol File: 302567-98-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, (4-methoxyphenyl)-, 9H-fluoren-9-ylmethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (4-methoxyphenyl)-, 9H-fluoren-9-ylmethyl ester (9CI)(302567-98-2)
• EPA Substance Registry System: Carbamic acid, (4-methoxyphenyl)-, 9H-fluoren-9-ylmethyl ester (9CI)(302567-98-2)

Safety Data

• Hazardous Substances Data: 302567-98-2(Hazardous Substances Data)

Upstream product

• 102774-86-7 9-fluorenylmethyl N-succinimidyl carbonate 
• 104-94-9 4-methoxy-aniline 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 

Relevant articles and documents

A greener, efficient and catalyst-free ultrasonic-assisted protocol for the n-fmoc protection of amines

A simple, eco-sustainable method for the N-(9-fluorenylmethoxycarbonyl) (N-Fmoc) protection of various structurally amines under ultrasonic irradiation is reported. The corresponding N-Fmoc derivatives were obtained in good to excellent yields within short reaction time. The reaction proceeds without the formation of any side product. Mildness, efficiency and easier work are the main advantages of this new protocol.

Copper-catalyzed mild nitration of protected anilines

A practical copper-catalyzed direct nitration of protected anilines, by using one equivalent of nitric acid as the nitrating agent, has been developed. This procedure features mild reaction conditions, wide structural scope (with regard to both N-protecting group and arene substitution), and high functional-group tolerance. Dinitration with two equivalents of nitric acid is also feasible. Practical and reliable: A Cu-catalyzed selective nitration of para- and ortho-substituted aniline derivatives by using one equivalent of HNO3 has been developed that produces water as the only stoichiometric byproduct (see scheme; PG=protecting group). This method is compatible with strongly electron-deficient substrates, enabling dinitration (by using 2.0 equiv of HNO3). This method allows for a rapid access to relevant nitrogen-containing heterocyclic architectures.

A rate enhancement of tert-butoxycarbonylation of aromatic amines with Boc2O in alcoholic solvents

A rate enhancement of tert-butoxycarbonylation of aromatic amines by Boc2O in alcohols compared to aprotic solvents was demonstrated. Kinetic analysis by NMR suggested that the reaction in CD3OD was faster than in CDCl3 by a factor of 70. Reactions between Boc2O and various aliphatic and aromatic amines in ethanol provided the N-Boc derivatives in good to excellent yields in short reaction times.