30267-80-2Relevant academic research and scientific papers
Synthesis and BK channel-opening activity of 2-amino-1,3-thiazole derivatives
Cui, Yong-Mei,Ji, Tong-Tong,Jo, Heeji,Lin, Hai-Xia,Park, Chul-Seung,Qi, Xiao-Lei,Wang, Xue-Ying
supporting information, (2021/05/19)
A series of 2-amino-5-arylmethyl- or 5-heteroarylmethyl-1,3-thiazole derivatives were synthesized and evaluated for BK channel-opening activities in cell-based fluorescence assay and electrophysiological recording. The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at benzene ring.
Carbene-Catalyzed α-Carbon Amination of Chloroaldehydes for Enantioselective Access to Dihydroquinoxaline Derivatives
Huang, Ruoyan,Chen, Xingkuan,Mou, Chengli,Luo, Guoyong,Li, Yongjia,Li, Xiangyang,Xue, Wei,Jin, Zhichao,Chi, Yonggui Robin
, p. 4340 - 4344 (2019/06/14)
An NHC-catalyzed α-carbon amination of chloroaldehydes was developed. Cyclohexadiene-1,2-diimines are used as amination reagents and four-atom synthons. Our reaction affords optically enriched dihydroquinoxalines that are core structures in natural products and synthetic bioactive molecules.
Synthesis and antitumor activities of new n-(5-benzylthiazol-2-yl)-2-(heteryl-5-ylsulfanyl)-acetamides
Ostapiuk, Yu. V.,Frolov,Vasylyschyn, R. Ya.,Matiychuk
, p. 59 - 71 (2018/05/15)
Aim. Synthesis of a series of new N-(5-benzyl-thiazol-2-yl)-2-(heteryl-5-ylsulfanyl)-acetamides and study of their anticancer activity. Methods. Organic synthesis, analytical and spectral methods, pharmacological screening. Results. [2-chloro-N-(5-aryl-1,
Carbene and Acid Cooperative Catalytic Reactions of Aldehydes and o-Hydroxybenzhydryl Amines for Highly Enantioselective Access to Dihydrocoumarins
Chen, Xingkuan,Song, Runjiang,Liu, Yingguo,Ooi, Chong Yih,Jin, Zhichao,Zhu, Tingshun,Wang, Hongling,Hao, Lin,Chi, Yonggui Robin
supporting information, p. 5892 - 5895 (2017/11/10)
A highly enantioselective method for quick access to dihydrocoumarins is reported. The reaction involves a cooperative catalytic process with carbene and in situ generated Br?nsted acid as the catalysts. α-Chloro aldehyde and readily available and stable
Heterocyclic Syntheses on the Basis of Anionarylation Products of Unsaturated Compounds. I. 2-Amino-5-arylmethyl-1,3-thiazoles
Obushak,Matiichuk,Ganushchak
, p. 1010 - 1013 (2007/10/03)
3-Aryl-2-chloropropionaldehydes have been prepared by reactions of arenediazonium chlorides with acrolein in the presence of CuCl2. Reactions of these aldehydes with thiourea provide a convenient route to difficultly accessible 2-amino-5-arylme
Process for the arylation of olefines
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, (2008/06/13)
A process for arylating an olefinic compound by addition of an aryl group to a double bond of said olefinic compound consisting in diazotizing an arylamine in an aqueous acidic solution comprising a lower alkanoic acid to form a solution of an aryldiazonium salt and reacting said aryldiazonium salt solution with an olefinic compound in an organic solvent in the presence of a catalytically effective amount of a copper halide. The amount of alkanoic acid is about 15 to 37% by volume of the total solvents used. The alkanoic acid is preferably acetic acid and the copper halide cuprous chloride.
