302840-63-7

Upstream product

• 3744-87-4 Boc-(R)-Ala 
• 626-43-7 3,5-Dichloroaniline 
• 109208-68-6 C₁₃H₂₃NO₆ 

Downstream Products

• 688756-00-5 (S)-2-[(R)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-5-(4-trifluoromethoxybenzyl)-6,7-dihydro-5H-imidazo[1,2-a]imidazol-3-ylsulfonylamino]propionamide 
• 1246745-48-1 (2R,5R)-5-(4-trifluoromethoxybenzyl)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trifluoroacetyl)-imidazolidin-4-one 
• 1175561-69-9 (R)-2-amino-3-(4-trifluoromethoxyphenyl)-N-(3,5-dichlorophenyl)-2-methylpropionamide p-toluenesulfonic acid salt 
• 688756-19-6 (R)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-5-(4-trifluoromethoxy-benzyl)-6,7-dihydro-5H-imidazo[1, 2-a]imidazole-3-sulfonyl chloride 
• 1246745-49-2 C₂₂H₂₂Cl₂F₃N₃O₄ 
• 1246745-49-2 C₂₂H₂₂Cl₂F₃N₃O₄ 
• 944580-11-4 (R)-N-(3,5-dichlorophenyl)-2-[3-(2,2-dimethoxyethyl)ureido]-2-methyl-3-(4-trifluoromethoxyphenyl)propionamide 
• 688756-17-4 (R)-1-(3,5-dichloro-phenyl)-3-methyl-3-(4-trifluoromethoxy-benzyl)-1H-imidazo[1,2-a]-imidazol-2-one 
• 341027-24-5 (2S,5R)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methylimidazolidin-4-one 
• 341027-25-6 (2R,5R)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trichloroacetyl)-imidazolidin-4-one 
• 1246745-52-7 (R)-3-(3,5-dichlorophenyl)-5-methyl-5-(4-trifluoromethoxybenzyl)imidazolidine-2,4-dione 
• 648422-58-6 (2R,5R)-5-(4-bromo-benzyl)-2-tert-butyl-3-(3,5-dichlorophenyl)-5-methyl-1-trifluoroacetyl-imidazolin-4-one 
• 213208-73-2 (5R)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methyl-1H-imidazole-2,4(3H,5H)-dione 
• 321724-17-8 (2S,5R)-2-tert-butyl-3-(3,5-dichlorophenyl)-5-methyl-1-trifluoroacetyl-imidazolidin-4-one 

Relevant academic research and scientific papers

Practical synthesis of a cell adhesion inhibitor by self-regeneration of stereocenters

An efficient enantiospecific synthesis of the cell adhesion inhibitor BIRT-377 by self-regeneration of stereocenters has been achieved in 38% overall yield in eight steps. The key transformations involve the stereoselective formation of the trans imidazol

Self-regeneration of stereocenters: A practical enantiospecific synthesis of LFA-1 antagonist BIRT-377

An efficient enantiospecific synthesis of the LFA-1 antagonist BIRT-377 has been achieved in 43percent overall yield in eight steps. The key transformations involve the stereospecific formation of the trans imidazolidinone 7, subsequent alkylation, and th