321724-17-8Relevant articles and documents
Self-regeneration of stereocenters: A practical enantiospecific synthesis of LFA-1 antagonist BIRT-377
Yee, Nathan K.
, p. 2781 - 2783 (2000)
An efficient enantiospecific synthesis of the LFA-1 antagonist BIRT-377 has been achieved in 43percent overall yield in eight steps. The key transformations involve the stereospecific formation of the trans imidazolidinone 7, subsequent alkylation, and th
Practical synthesis of a cell adhesion inhibitor by self-regeneration of stereocenters
Yee, Nathan K.,Nummy, Laurence J.,Frutos, Rogelio P.,Song, Jinhua J.,Napolitano, Elio,Byrne, Denis P.,Jones, Paul-James,Farina, Vittorio
, p. 3495 - 3501 (2007/10/03)
An efficient enantiospecific synthesis of the cell adhesion inhibitor BIRT-377 by self-regeneration of stereocenters has been achieved in 38% overall yield in eight steps. The key transformations involve the stereoselective formation of the trans imidazol