302843-01-2Relevant academic research and scientific papers
Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors
Szermerski, Marina,Melesina, Jelena,Wichapong, Kanin,L?ppenberg, Marius,Jose, Joachim,Sippl, Wolfgang,Holl, Ralph
, p. 1016 - 1028 (2014/02/14)
The inhibition of the UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase (LpxC) represents a promising strategy to combat infections caused by multidrug-resistant Gram-negative bacteria In order to elucidate the functional groups being impor
Anti-selective glycolate aldol additions with an oxapyrone boron enolate
Andrus, Merritt B.,Sekhar, B. B. V. Soma,Meredith, Erik L.,Dalley, N. Kent
, p. 3035 - 3037 (2007/10/03)
The boron enolate of pyrone 2 undergoes asymmetric aldol reactions with aldehydes to give protected anti 1,2-diols 3. The pyrone is readily available from trans stilbene using asymmetric dihydroxylation. Yields for the aldol reaction range from 62 to 92%
