25779-13-9

Basic information

• Product Name: (S)-(+)-1-Phenyl-1,2-ethanediol
• Synonyms: (S)-(+)-1-Phenyl-1,2-ethanediol 99%;(S)-1-Phenyl-1,2-ethanediol,99%e.e.;(S)-(+)-1-PHENYLETHANEDIOL;(S)-(-)-1-PHENYL-1,2-ETHANEDIOL;(S)-(+)-1-PHENYL-1,2-ETHANEDIOL;(S)-1-PHENYL-1,2-ETHANEDIOL;(S)-(+)-1,2-PHENYLETHANEDIOL;(S)-(+)-1-Phenyl-1,2-ethanediol, 99+%
• CAS NO: 25779-13-9
• Molecular Formula: C₈H₁₀O₂
• Molecular Weight: 138.16
• Product Categories: Chiral Compounds;Diols;chiral;Chiral Building Blocks;Simple Alcohols (Chiral);Synthetic Organic Chemistry;Aromatics;Chiral Reagents;Intermediates
• Mol File: 25779-13-9.mol
• Article Data: 295

Chemical Properties

• Melting Point: 64-67 °C(lit.)
• Boiling Point: 272-274 °C (755 mmHg)
• Flash Point: 320 °F
• Appearance: white to light yellow crystal powder
• Density: 1.0742 (rough estimate)
• Vapor Pressure: 0.00278mmHg at 25°C
• Refractive Index: 40 ° (C=3, H2O)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 13.61±0.20(Predicted)
• Water Solubility: soluble
• BRN: 3196197
• CAS DataBase Reference: (S)-(+)-1-Phenyl-1,2-ethanediol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-1-Phenyl-1,2-ethanediol(25779-13-9)
• EPA Substance Registry System: (S)-(+)-1-Phenyl-1,2-ethanediol(25779-13-9)

Safety Data

• Hazard Codes: Xi,T
• Statements: 23/24/25-36/37/38
• Safety Statements: 24/25-45-36/37/39-26
• WGK Germany: 3
• Hazardous Substances Data: 25779-13-9(Hazardous Substances Data)

Usage

Chemical Properties

(S)-(+)-1-Phenyl-1,2-ethanediol is white to light yellow crystal powde

Uses

Different sources of media describe the Uses of 25779-13-9 differently. You can refer to the following data:
1. (S)-(+)-1-Phenyl-1,2-ethanediol used as a chiral building block in organic synthesis, used in the preparation of chiral 2-amino-1-phenylethanols as pharmaceutical intermediates.
2. Extremely valuable and versatile alcohol used as a chiral building block in organic synthesis, used in the preparation of chiral 2-amino-1-phenylethanols as pharmaceutical intermediates.

InChI:InChI=1/C8H10O2/c9-6-8(10)7-4-2-1-3-5-7/h1-5,8-10H,6H2/t8-/m1/s1

Upstream product

• 21210-43-5 (S)-Methyl mandelate 
• 54797-42-1 2-oxo-2-phenylethyl propionate 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 22094-21-9 2-acetoxy-2-phenylacetaldehyde 
• 269402-51-9 (R)-2-methyloxymethoxy-2-phenyl-1-ethanol 
• 20780-53-4 (R)-Styrene oxide 
• 56751-12-3 2-chloro-1-phenylethanol 
• 532-27-4 1-chloroacetophenone 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 114091-75-7 (1R,2Z,4S)-4-<(2-Methoxyethoxy)methoxy>-1-phenyl-2-penten-1-ol 
• 17199-29-0 L-(+)-mandelic acid 
• 114091-81-5 (Z)-(S)-5-(2-Methoxy-ethoxymethoxy)-2-phenyl-hex-3-en-2-ol 
• 54797-43-2 Butyric acid 2-oxo-2-phenyl-ethyl ester 
• 26205-41-4 2-[(trimethylsilyl)oxy]acetophenone 

Downstream Products

• 133007-27-9 (3R,7aS)-3-phenyl-2,3,5,6,7,7a-hexahydropyrrolo[2,1-b]oxazol-5-one 
• 158271-95-5 1-(2-hydroxy-1-phenylethyl)-1,5-dihydropyrrol-2-one 
• 70111-04-5 (S)-(2-hydroxy-2-phenyl)ethyl benzoate 
• 1173179-78-6 (S)-1-phenylethane-1,2-diyl bis(4-nitrobenzoate) 
• 17199-29-0 (S)-Mandelic acid 
• 875-74-1 (R)-phenylglycine 
• 2935-35-5 (S)-2-phenylglycine 
• 611-73-4 Benzoylformic acid 
• 34025-29-1 (S)-2-hydroxy-2-phenylacetaldehyde 
• 103548-09-0 (S)-2-((tert-butyldimethylsilyl)oxy)-1-phenylethan-1-ol 
• 115-22-0 3-Hydroxy-3-methyl-2-butanone 
• 4427-92-3 (4S)-4-phenyl[1,3]dioxolan-2-one 
• 126923-26-0 (R)-2-azido-2-phenylethan-1-ol 
• 127707-63-5 2-phenyl-2-hydroxyethyl acetate 

Relevant articles and documents

Marked improvement in the asymmetric reduction of 2-hydroxyacetophenone with mut-AcCR in a biphasic system

(S)-1-Phenyl-1,2-ethanediol (PED) is a vital chiral block in specialty chemical industries. The biotransformation of 2-hydroxyacetophenone (2-HAP) to (S)-PED was conducted successfully catalyzed with BL21(DE3)(pETDuet-gst-mut-accr-gdh) which harboring a c

Coexpression of a carbonyl reductase and glucose 6-phosphate dehydrogenase in Pichia pastoris improves the production of (S)-1-phenyl-1,2-ethanediol

To develop an efficient biocatalyst to produce optically active (S)-phenyl ethanediol (PED), a carbonyl reductase SCRII and glucose 6-phosphate dehydrogenase were coexpressed intracellularly in Pichia pastoris. The recombinant enzyme PpSCRII was purified

Tridentate nitrogen phosphine ligand containing arylamine NH as well as preparation method and application thereof

The invention discloses a tridentate nitrogen phosphine ligand containing arylamine NH as well as a preparation method and application thereof, and belongs to the technical field of organic synthesis. The tridentate nitrogen phosphine ligand disclosed by the invention is the first case of tridentate nitrogen phosphine ligand containing not only a quinoline amine structure but also chiral ferrocene at present, a noble metal complex of the type of ligand shows good selectivity and extremely high catalytic activity in an asymmetric hydrogenation reaction, meanwhile, a cheap metal complex of the ligand can also show good selectivity and catalytic activity in the asymmetric hydrogenation reaction, and is very easy to modify in the aspects of electronic effect and space structure, so that the ligand has huge potential application value. A catalyst formed by the ligand and a transition metal complex can be used for catalyzing various reactions, can be used for synthesizing various drugs, and has important industrial application value.

Diversity and oriented synthesis of clopidogrel drug derivatives

An efficient synthetic route has been developed for the synthesis of new clopidogrel drug derivatives. Key step of this method is to replacement of mesyl protected alcohol group with various aliphatic amines in presence of base. Various clopidogrel drug d