302910-90-3Relevant academic research and scientific papers
Efficient synthesis of tertiary amines from secondary amines
Kurosu, Michio,Dey, Sevendu Sekhar,Crick, Dean C.
, p. 4871 - 4875 (2007/10/03)
Reliable N-alkylations of secondary amines have been developed. By using DIAD and TPP (or PS-TPP) a variety of secondary amines can be converted to the corresponding tertiary amines in good to excellent yields with diverse alkylhalides; no formation of quaternary amine salts are observed. These protocols are amenable to combinatorial chemistry libraries, and are also useful for the syntheses of secondary amines by an acid lysis of the cleavable tertiary amino resins.
Solid-phase synthesis of tertiary methylamines via reductive alkylation-fragmentation using a hydroxylamine linker
Blaney,Grigg,Rankovic,Thoroughgood
, p. 6635 - 6638 (2007/10/03)
The solid-phase synthesis of tertiary methylamines via reductive alkylation-fragmentation employing a hydroxylamine linker is described. The hydroxylamine linker is traceless, robust and versatile, allowing strong organometallic reagents to be used in the synthesis of diverse tertiary methylamines. (C) 2000 Elsevier Science Ltd.
