302965-08-8Relevant articles and documents
6-O-Glycosylation of morphine derivatives using thioglycosides as glycosyl donors
Rukhman,Yudovich,Nisnevich,Gutman
, p. 1241 - 1246 (2007/10/03)
A novel approach was developed for the synthesis of the pharmaceutically important morphine and dihydromorphine 6-β-D-glucuronides. The key step involves a selective 6-O-glycosylation of 3-O-protected morphines and dihydromorphines with thioglycosides that serve as glycosyl donors in the presence of thiophilic promoters. This novel approach may be useful for the O-glycosylation of other alkoloid derivatives.