169776-86-7Relevant academic research and scientific papers
Synthesis of acyclic nucleoside and nucleotide analogs derived from 6-amino-7H-purin-8(9H)-one
Janeba, Zlatko,Holy, Antonin,Masojidkova, Milena
, p. 1126 - 1144 (2007/10/03)
Reaction of 8-bromoadenine derivatives 2 with sodium acetate in acetic acid and cleavage of (S)-7-[(trityloxy)methyl]-7,8-dihydro[1,3]oxazolo[3,2-e]purin-4-amine (12) and diisopropyl (S)-[[(4-amino-8,9-dihydro-7H-[1,3]oxazino[3,2-e]purin-8-yl)oxy]methyl]phosphona te (13a) were used for the synthesis of the corresponding N9-substituted derivatives of 6-amino-7H-purin-8(9H)-one 3a-3c and 7. Alkylation of 6-amino-7H-purin-8(9H)-one (3a) with diverse alkylation agents afforded the title N9-monosubstituted 3b, 3d and 7a and N7,N9-disubstituted acyclic nucleoside and nucleotide analogs 6b, 6d and 8a.
Reaction of 8-Substituted Adenines with Glycidol
Ratsino, E. V.,Radchenko, S. I.
, p. 273 - 275 (2007/10/03)
The regioselectivity of isomer formation in the reaction of 8-substituted adenines with glycidol depends on steric factors of substituents.The compounds prepared were tested for immunostimulating activity.
