30311-35-4Relevant academic research and scientific papers
Mesogen-jacketed liquid crystalline polymers substituted with oligo(oxyethylene) as peripheral chain
Liang, Xiaochao,Chen, Xiaofang,Li, Christopher Y.,Shen, Zhihao,Fan, Xinghe,Zhou, Qifeng
experimental part, p. 3693 - 3705 (2011/11/01)
Mesogen-jacketed liquid crystalline polymer (MJLCP) is a typical rod-shaped macromolecule. Its unique molecular architecture allows one to tune the geometric parameters of the macromolecular rod. Moreover, the rod surface chemistry can be controlled by de
Synthesis, photophysical properties and in vitro photodynamic activity of axially substituted subphthalocyanines
Xu, Hu,Jiang, Xiong-Jie,Chan, Elaine Y. M.,Fong, Wing-Ping,Ng, Dennis K. P.
, p. 3987 - 3992 (2008/10/09)
A new series of subphthalocyanines substituted axially with an oligoethylene glycol chain [SPcB(OCH2CH2)nOH, n = 3 (2) or 4 (3)] or a p-phenoxy oligoethylene glycol methyl ether chain [SPcBOC6H4(OCH2CH2) nOCH3, n = 2 (4) or 3 (5)] have been synthesised by substitution reactions of boron subphthalocyanine chloride SPcBCl (1) with the corresponding oligoethylene glycols, and characterised with various spectroscopic methods and elemental analysis. The molecular structure of one of these compounds (subphthalocyanine 4) has also been determined. As revealed by absorption spectroscopy, these compounds are essentially non-aggregated in DMF. The low aggregation tendency of these compounds results in a strong fluorescence emission and high efficiency to generate singlet oxygen. All these subphthalocyanines, being formulated with Cremophor EL, function as efficient photosensitisers and exhibit a high photocytotoxicity against HepG2 human hepatocarcinoma and HT29 human colon adenocarcinoma cells. The phenoxy analogues 4 and 5 show a relatively high photostability and are particularly potent towards these cell lines, with IC50 values down to 0.02 μM. This journal is The Royal Society of Chemistry.
Enhancing the aqueous solubility of d4T-based phosphoramidate prodrugs
Siddiqui, Adam,McGuigan, Christopher,Ballatore, Carlo,Srinivasan, Sheila,De Clercq, Erik,Balzarini, Jan
, p. 381 - 384 (2007/10/03)
A range of polyether para-substituted phosphoramidates were synthesised and found to have substantially elevated aqueous solubilities compared to the underivatised parent prodrug. A 30-fold increase in aqueous solubility could be achieved without a substantial decrease of in vitro activity against HIV-1. Replacement of the aryl (i.e. phenolic) moiety by tyrosine led to a substantial enhancement in aqueous solubility but also to a decrease in antiviral potency. A previously unobserved trend was identified, relating increased aryl substituent steric bulk to decreased antiviral activity. (C) 2000 Elsevier Science Ltd. All rights reserved.
Cyclobis(paraquat-4,4'-biphenylene) - An Organic Molecular Square
Asakawa, Masumi,Ashton, Peter R.,Menzer, Stephan,Raymo, Francisco M.,Stoddart, J. Fraser,et al.
, p. 877 - 893 (2007/10/03)
Template-directed syntheses of cyclobis(paraquat-4,4'-biphenylene) (1) - a molecular square - have been achieved by use of ?-electron-rich macrocyclic hydroquinone-based and acyclic ferrocene-based templates.In particular, the use of a polyether-disubstituted ferrocene derivative as a template permits synthesis of 1 (which is accessible only in very low yields without templates) on a preparative scale.Furthermore, the use of a macrocyclic hydroquinone-based polyether template incorporating an ester function in one polyether chain - an "oriented" macrocycle - affords a 1:1 mixture of two topologically stereoisomers catenanes.Ester hydrolysis of the ?-electron-rich macrocyclic components mechanically interlocked with 1 within the catenated structures releases the tetracationic cyclophane in quantitative yield as a result of the degradation of the catenanes.The molecular square has been characterized by X-ray crystallography, FAB mass spectrometry, 1H NMR and 13C NMR spectroscopies, and elemental analysis.The binding properties of 1 and of the smaller cyclophane cyclobis(paraquat-p-phenylene) toward a series of ?-electron-rich guests have also been investigated with the above techniques and UV/VIS spectroscopy.The self-assembly of the resulting supramolecular complexes in solution and in the solid state is driven mainly by ?-? stacking interactions and hydrogen-bonding interactions, as well as by edge-to-face T-type interactions.In particular, the complexation of ferrocene or a ferrocene-based derivative within the cavity of 1 suggests the possibility of constructing functioning ferrocene-based molecular and supramolecular devices that can be controlled electrochemically in the form of catenanes, rotaxanes, and pseudorotaxanes. -Keywords: catenanes; second-sphere coordination; self-assembly; template syntheses; topological stereoisomerism
