30312-88-0

Basic information

• Product Name: Butanoyl chloride, 4-(4-nitrophenoxy)-
• CAS NO: 30312-88-0
• Molecular Formula: C10H10ClNO4
• Molecular Weight: 243.647
• Mol File: 30312-88-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Butanoyl chloride, 4-(4-nitrophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoyl chloride, 4-(4-nitrophenoxy)-(30312-88-0)
• EPA Substance Registry System: Butanoyl chloride, 4-(4-nitrophenoxy)-(30312-88-0)

Safety Data

• Hazardous Substances Data: 30312-88-0(Hazardous Substances Data)

Upstream product

• 100-02-7 4-nitro-phenol 
• 28341-53-9 methyl 4-(4-nitrophenoxy)butyrate 
• 99072-20-5 4-(4-nitrophenoxy)butanenitrile 
• 28341-54-0 4-(4-nitrophenoxy)butanoic acid 

Relevant articles and documents

The discovery and optimization of novel dual inhibitors of topoisomerase ii and histone deacetylase

A novel class of podophyllotoxin derivatives have been designed and synthesized based on the synergistic antitumor effects of topoisomerase II and histone deacetylase inhibitors. Their inhibitory activities towards histone deacetylases and Topo II and their cytotoxicities in cancer cell lines were evaluated. The aromatic capping group connection, linker length and zinc-binding group were systematically varied and preliminary conclusions regarding structure-activity relationships are discussed. Among all of the synthesized hybrid compounds, compound 24d showed the most potent HDAC inhibitory activity at a low nanomolar level and exhibited powerful antiproliferative activity towards HCT116 colon carcinoma cells at a low micromolar level. Further exploration of this series led to the discovery of potent dual inhibitor 32, which exhibited the strongest in vitro cytotoxic activity.