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28341-53-9

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28341-53-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 28341-53-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,3,4 and 1 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 28341-53:
(7*2)+(6*8)+(5*3)+(4*4)+(3*1)+(2*5)+(1*3)=109
109 % 10 = 9
So 28341-53-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H13NO5/c1-16-11(13)3-2-8-17-10-6-4-9(5-7-10)12(14)15/h4-7H,2-3,8H2,1H3

28341-53-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 4-(4-nitrophenoxy)butanoate

1.2 Other means of identification

Product number -
Other names p-Nitro-phenoxy-buttersaeure-methylester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:28341-53-9 SDS

28341-53-9Relevant articles and documents

The discovery and optimization of novel dual inhibitors of topoisomerase ii and histone deacetylase

Zhang, Xuan,Bao, Bin,Yu, Xiuhua,Tong, Linjiang,Luo, Yu,Huang, Qingqing,Su, Mingbo,Sheng, Li,Li, Jia,Zhu, Hong,Yang, Bo,Zhang, Xiongwen,Chen, Yi,Lu, Wei

, p. 6981 - 6995 (2013/11/06)

A novel class of podophyllotoxin derivatives have been designed and synthesized based on the synergistic antitumor effects of topoisomerase II and histone deacetylase inhibitors. Their inhibitory activities towards histone deacetylases and Topo II and their cytotoxicities in cancer cell lines were evaluated. The aromatic capping group connection, linker length and zinc-binding group were systematically varied and preliminary conclusions regarding structure-activity relationships are discussed. Among all of the synthesized hybrid compounds, compound 24d showed the most potent HDAC inhibitory activity at a low nanomolar level and exhibited powerful antiproliferative activity towards HCT116 colon carcinoma cells at a low micromolar level. Further exploration of this series led to the discovery of potent dual inhibitor 32, which exhibited the strongest in vitro cytotoxic activity.

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