303134-85-2Relevant academic research and scientific papers
Discovery of N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (darexaban, YM150) as a potent and orally available factor Xa inhibitor
Hirayama, Fukushi,Koshio, Hiroyuki,Ishihara, Tsukasa,Hachiya, Shunichiro,Sugasawa, Keizo,Koga, Yuji,Seki, Norio,Shiraki, Ryouta,Shigenaga, Takeshi,Iwatsuki, Yoshiyuki,Moritani, Yumiko,Mori, Kenichi,Kadokura, Takeshi,Kawasaki, Tomihisa,Matsumoto, Yuzo,Sakamoto, Shuichi,Tsukamoto, Shin-Ichi
, p. 8051 - 8065 (2012/03/08)
Inhibitors of factor Xa (FXa), a crucial serine protease in the coagulation cascade, have attracted a great deal of attention as a target for developing antithrombotic agents. We previously reported findings from our optimization study of a high-throughpu
