303175-79-3Relevant academic research and scientific papers
Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors
Ahonen, Tiina J.,Rinne, Maiju,Grutschreiber, Peter,M?tlik, Kert,Airavaara, Mikko,Schaarschmidt, Dieter,Lang, Heinrich,Reiss, David,Xhaard, Henri,Gaveriaux-Ruff, Claire,Yli-Kauhaluoma, Jari,Moreira, Vania M.
, p. 495 - 507 (2018)
Despite extensive years of research, the direct oxidation of the 7,8-double bond of opioids has so far received little attention and knowledge about the effects of this modification on activity at the different opioid receptors is scarce. We herein report
Selective protection and functionalization of morphine: Synthesis and opioid receptor binding properties of 3-amino-3-desoxymorphine derivatives
Wentland,Duan,Cohen,Bidlack
, p. 3558 - 3565 (2007/10/03)
As part of an effort to identify novel opioid receptor interactive agents, we recently prepared a series of 8-(substituted)amino analogues of cyclazocine. We found the chiral 8-phenylamino (NHC6H5) cyclazocine derivative to have subn
