303183-83-7Relevant academic research and scientific papers
Asymmetric oxidation of 3-alkyl-1,2-cyclopentanediones. Part 2: Oxidative ring cleavage of 3-alkyl-1,2-cyclopentanediones: Synthesis of 2-alkyl-γ-lactone acids
Paju, Anne,Kanger, Tonis,Pehk, Tonis,Lindmaa, Rasmus,Mueuerisepp, Aleksander-Mati,Lopp, Margus
, p. 1565 - 1573 (2003)
Ti(OiPr)4/diethyl tartrate/tBuOOH system oxidizes 3-alkyl-1,2-cyclopentanediones resulting in hydroxylated ring cleavage products 2-alkyl-γ-lactone acids, in high enantioselectivity (～95% ee) and satisfactory isolated yields (up to 55%).
Asymmetric oxidation of 3-alkyl-1,2-cyclopentanediones. Part 1: 3-Hydroxylation of 3-alkyl-1,2-cyclopentanediones
Paju, Anne,Kanger, Tonis,Pehk, Tonis,Mueuerisepp, Aleksander-Mati,Lopp, Margus
, p. 2439 - 2448 (2007/10/03)
3-Alkyl-1,2-cyclopentanediones undergo asymmetric 3-hydroxylation with the Sharpless Ti-complex resulting in enantiomeric 3-hydroxy carbonyl compounds with ee up to 95% in yields of 22-40%.
